STK24 serine/threonine kinase 24 [Homo sapiens (human)] - Gene

Summary

Official Symbol: STK24provided by HGNC
Official Full Name: serine/threonine kinase 24provided by HGNC
Primary source: HGNC:HGNC:11403
See related: Ensembl:ENSG00000102572 MIM:604984; AllianceGenome:HGNC:11403
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MST3; STK3; MST3B; STE20; HEL-S-95
Summary: This gene encodes a serine/threonine protein kinase that functions upstream of mitogen-activated protein kinase (MAPK) signaling. The encoded protein is cleaved into two chains by caspases; the N-terminal fragment (MST3/N) translocates to the nucleus and promotes programmed cells death. There is a pseudogene for this gene on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
Expression: Ubiquitous expression in esophagus (RPKM 41.4), skin (RPKM 24.6) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 13q32.2

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	13	NC_000013.11 (98445185..98577107, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	13	NC_060937.1 (97652976..97785805, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	13	NC_000013.10 (99097439..99229361, complement)

Chromosome 13 - NC_000013.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protein Kinase STK24 Promotes Tumor Immune Evasion via the AKT-PD-L1 Axis.
Title: Protein Kinase STK24 Promotes Tumor Immune Evasion via the AKT-PD-L1 Axis.
STE20-type kinases MST3 and MST4 promote the progression of hepatocellular carcinoma: Evidence from human cell culture and expression profiling of liver biopsies.
Title: STE20-type kinases MST3 and MST4 promote the progression of hepatocellular carcinoma: Evidence from human cell culture and expression profiling of liver biopsies.
Serine/threonine-protein kinase STK24 induces tumorigenesis by regulating the STAT3/VEGFA signaling pathway.
Title: Serine/threonine-protein kinase STK24 induces tumorigenesis by regulating the STAT3/VEGFA signaling pathway.
STK24 modulates excitatory synaptic transmission in epileptic hippocampal neurons.
Title: STK24 modulates excitatory synaptic transmission in epileptic hippocampal neurons.
MST3 protein coats lipid droplets in human liver cells. Knockdown of MST3 attenuated lipid accumulation in human hepatocytes by stimulating beta-oxidation and triacylglycerol secretion while inhibiting fatty acid influx and lipid synthesis. MST3 expression was positively correlated with key features of NASH in human liver biopsies.
Title: Protein kinase MST3 modulates lipid homeostasis in hepatocytes and correlates with nonalcoholic steatohepatitis in humans.
Down-expression of MST3 in colorectal cancer cell lines enhanced their migration and invasion, but overexpression of MST3 could attenuate miR-222 overexpression in the promotion of migration and invasion in colorectal cell lines.
Title: microRNA-222 promotes colorectal cancer cell migration and invasion by targeting MST3.
Aberrant STK24 expression was an independent prognostic indicator in lung adenocarcinoma patients. Its dysregulation was associated with its DNA copy number alteration and methylation.
Title: STK24 expression is modulated by DNA copy number/methylation in lung adenocarcinoma and predicts poor survival.
High MST3 expression is associated with breast cancer.
Title: MST3 promotes proliferation and tumorigenicity through the VAV2/Rac1 signal axis in breast cancer.
This study demonistrated that MST3 kinase phosphorylates TAO1/2 to enable Myosin Va function in promoting spine synapse development.
Title: MST3 kinase phosphorylates TAO1/2 to enable Myosin Va function in promoting spine synapse development.
This review notes that in the SOK1 and MST4 germinal center kinase III family of proteins, exon 1 encodes a 5' untranslated region, but this is not the case for MST3.
Title: SOcK, MiSTs, MASK and STicKs: the GCKIII (germinal centre kinase III) kinases and their heterologous protein-protein interactions.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A comprehensive genetic association study of Alzheimer disease in African Americans. EBI GWAS Catalog EBI GWAS CatalogPubMed
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method. EBI GWAS Catalog EBI GWAS CatalogPubMed
GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. EBI GWAS Catalog EBI GWAS CatalogPubMed
Joint influence of small-effect genetic variants on human longevity. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Screening in Jurkat T-cells with a short-hairpin-RNA (shRNA) library identifies serine/threonine kinase 24 STK24 is important for HIV-1 replication	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH48488 (e-PCR)
- UniSTS:57654

RH65722 (e-PCR)
- UniSTS:30532

WI-12444 (e-PCR)
- UniSTS:13144

D13S1172 (e-PCR)
- UniSTS:66674

D13S678E (e-PCR)
- UniSTS:153211

RH65146 (e-PCR)
- UniSTS:29887

RH48394 (e-PCR)
- UniSTS:60618

RH45044 (e-PCR)
- UniSTS:48120

RH44984 (e-PCR)
- UniSTS:67071

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables cadherin binding	HDA more info	PubMed
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	TAS Traceable Author Statement more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to oxidative stress	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in execution phase of apoptosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intrinsic apoptotic signaling pathway in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of axon regeneration	IEA Inferred from Electronic Annotation more info
involved_in protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein autophosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of axon regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of FAR/SIN/STRIPAK complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	TAS Traceable Author Statement more info	PubMed
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	TAS Traceable Author Statement more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: serine/threonine-protein kinase 24

Names: STE20-like kinase 3; STE20-like kinase MST3; epididymis secretory protein Li 95; mammalian STE20-like protein kinase 3; serine/threonine kinase 24 (STE20 homolog, yeast); sterile 20-like kinase 3

NP_001027467.2

EC 2.7.11.1

NP_001273578.1

EC 2.7.11.1

NP_003567.2

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001032296.4 → NP_001027467.2 serine/threonine-protein kinase 24 isoform b precursor

See identical proteins and their annotated locations for NP_001027467.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.

Source sequence(s)

AL137249, AL356423

Consensus CDS

CCDS32001.1

UniProtKB/TrEMBL

Q5U0E6, Q6FG81, Q6P0Y1

Related

ENSP00000442539.2, ENST00000539966.6

Conserved Domains (1) summary

cd06609
Location:22 → 295

STKc_MST3_like; Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases
NM_001286649.2 → NP_001273578.1 serine/threonine-protein kinase 24 isoform c precursor

See identical proteins and their annotated locations for NP_001273578.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and contains multiple differences in the coding region, compard to variant 1, including initiation of translation at an alternate start codon. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a.

Source sequence(s)

AL137249, AL356423

Consensus CDS

CCDS66573.1

UniProtKB/TrEMBL

B4DR80, Q6FG81, Q6P0Y1

Related

ENSP00000380651.3, ENST00000397517.6

Conserved Domains (1) summary

cd06609
Location:22 → 276

STKc_MST3_like; Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases
NM_003576.5 → NP_003567.2 serine/threonine-protein kinase 24 isoform a precursor

See identical proteins and their annotated locations for NP_003567.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (a, also known as MST3b).

Source sequence(s)

AL137249, AL356423

Consensus CDS

CCDS9488.1

UniProtKB/Swiss-Prot

O14840, Q5JV92, Q9Y6E0

UniProtKB/TrEMBL

Q6FG81, Q6P0Y1

Related

ENSP00000365730.3, ENST00000376547.7

Conserved Domains (1) summary

cd06609
Location:34 → 307

STKc_MST3_like; Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases