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    Mblac2 metallo-beta-lactamase domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 72852, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mblac2provided by MGI
    Official Full Name
    metallo-beta-lactamase domain containing 2provided by MGI
    Primary source
    MGI:MGI:1920102
    See related
    Ensembl:ENSMUSG00000051098 AllianceGenome:MGI:1920102
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2900024O10Rik
    Summary
    Predicted to enable beta-lactamase activity and long-chain fatty acyl-CoA hydrolase activity. Predicted to be involved in fatty acid metabolic process. Predicted to be located in endoplasmic reticulum membrane and plasma membrane. Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human MBLAC2 (metallo-beta-lactamase domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 8.8), frontal lobe adult (RPKM 6.0) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mblac2 in Genome Data Viewer
    Location:
    13 C3; 13 43.68 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (81859536..81901394)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (81711417..81753275)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene LysM, putative peptidoglycan-binding, domain containing 3 Neighboring gene polymerase (RNA) III (DNA directed) polypeptide G Neighboring gene STARR-seq mESC enhancer starr_35131 Neighboring gene STARR-positive B cell enhancer ABC_E11550 Neighboring gene STARR-seq mESC enhancer starr_35132 Neighboring gene STARR-positive B cell enhancer ABC_E604 Neighboring gene STARR-positive B cell enhancer ABC_E3088 Neighboring gene centrin 3 Neighboring gene STARR-positive B cell enhancer ABC_E7258 Neighboring gene STARR-seq mESC enhancer starr_35135 Neighboring gene STARR-seq mESC enhancer starr_35136 Neighboring gene predicted gene, 32836

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Gene expression in the developing mouse retina by EST sequencing and microarray analysis. Mu X, et al. Nucleic Acids Res, 2001 Dec 15. PMID 11812828, Free PMC Article
    2. The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. Sansom SN, et al. PLoS Genet, 2009 Jun. PMID 19521500, Free PMC Article
    3. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
    4. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables beta-lactamase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables beta-lactamase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables long-chain fatty acyl-CoA hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables long-chain fatty acyl-CoA hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    acyl-coenzyme A thioesterase MBLAC2
    Names
    acyl-CoA thioesterase MBLAC2
    beta-lactamase MBLAC2
    metallo-beta-lactamase domain-containing protein 2
    palmitoyl-coenzyme A thioesterase MBLAC2
    NP_082648.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028372.1 → NP_082648.1  acyl-coenzyme A thioesterase MBLAC2

      See identical proteins and their annotated locations for NP_082648.1

      Status: PROVISIONAL

      Source sequence(s)
      AK046032, BU559276, CAAA01027445
      Consensus CDS
      CCDS26662.1
      UniProtKB/Swiss-Prot
      G3X997, Q8BL86
      Related
      ENSMUSP00000051644.6, ENSMUST00000057598.7
      Conserved Domains (1) summary
      cd07712
      Location:22 → 231
      MBLAC2-like_MBL-fold; uncharacterized human metallo-beta-lactamase domain-containing protein 2 and related proteins; MBL-fold metallo hydrolase domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      81859536..81901394
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BL86.2 GenPept UniProtKB/Swiss-Prot:Q8BL86

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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