Tut1 terminal uridylyl transferase 1, U6 snRNA-specific [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tut1provided by RGD
Official Full Name: terminal uridylyl transferase 1, U6 snRNA-specificprovided by RGD
Primary source: RGD:1561043
See related: AllianceGenome:RGD:1561043
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including RNA binding activity; enzyme-substrate adaptor activity; and nucleotidyltransferase activity. Predicted to be involved in U6 snRNA 3'-end processing and co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway. Predicted to be located in cytosol and nucleolus. Predicted to be part of mRNA cleavage and polyadenylation specificity factor complex. Predicted to be active in mitochondrion and nuclear speck. Orthologous to human TUT1 (terminal uridylyl transferase 1, U6 snRNA-specific). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 107.7), Thymus (RPKM 89.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (215277802..215288869)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (205848691..205859767)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (225151462..225162445)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The loss of NQO1 during hypertrophy was rescued by ectopic expression of the distal- but not the proximal- or middle-specific NQO1 mRNA isoforms in the presence of Star-PAP expression, and reverses molecular events of hypertrophy in cardiomyocytes.
Title: Star-PAP controlled alternative polyadenylation coupled poly(A) tail length regulates protein expression in hypertrophic heart.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH131360 (e-PCR)
- UniSTS:214643

RH142582 (e-PCR)
- UniSTS:231829

AU049691 (e-PCR)
- UniSTS:146137

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables RNA uridylyltransferase activity	ISO Inferred from Sequence Orthology more info
enables RNA uridylyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables U6 snRNA binding	ISO Inferred from Sequence Orthology more info
enables U6 snRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables enzyme-substrate adaptor activity	ISO Inferred from Sequence Orthology more info
enables enzyme-substrate adaptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA 3'-UTR binding	ISO Inferred from Sequence Orthology more info
enables mRNA 3'-UTR binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables poly(A) RNA polymerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables poly(A) RNA polymerase activity	ISO Inferred from Sequence Orthology more info
enables poly(A) RNA polymerase activity	ISS Inferred from Sequence or Structural Similarity more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA 3'-end processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in RNA metabolic process	IEA Inferred from Electronic Annotation more info
involved_in U6 snRNA 3'-end processing	ISO Inferred from Sequence Orthology more info
involved_in U6 snRNA 3'-end processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway	ISO Inferred from Sequence Orthology more info
involved_in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in histone mRNA catabolic process	ISO Inferred from Sequence Orthology more info
NOT involved_in histone mRNA catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in mRNA 3'-end processing	ISO Inferred from Sequence Orthology more info
involved_in snRNA processing	ISO Inferred from Sequence Orthology more info
involved_in snRNA processing	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of mRNA cleavage and polyadenylation specificity factor complex	ISO Inferred from Sequence Orthology more info
part_of mRNA cleavage and polyadenylation specificity factor complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nuclear speck	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: speckle targeted PIP5K1A-regulated poly(A) polymerase

Names: RNA-binding motif protein 21; RNA-binding protein 21; U6 snRNA-specific terminal uridylyltransferase 1; U6-TUTase; star-PAP

NP_001029073.1

EC 2.7.7.19

EC 2.7.7.52

XP_063127683.1

EC 2.7.7.19

EC 2.7.7.52

XP_063127685.1

EC 2.7.7.19

EC 2.7.7.52

XP_063127687.1

EC 2.7.7.19

EC 2.7.7.52

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033901.1 → NP_001029073.1 speckle targeted PIP5K1A-regulated poly(A) polymerase

See identical proteins and their annotated locations for NP_001029073.1

Status: PROVISIONAL

Source sequence(s)

BC104695

UniProtKB/Swiss-Prot

Q3MHT4

UniProtKB/TrEMBL

A0A8I6ADU1, A6HZY1

Conserved Domains (5) summary

cd05402
Location:331 → 401

NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases

smart00451
Location:14 → 47

ZnF_U1; U1-like zinc finger

COG0724
Location:56 → 140

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12279
Location:54 → 127

RRM_TUT1; RNA recognition motif in speckle targeted PIP5K1A-regulated poly(A) polymerase (Star-PAP) and similar proteins

pfam03828
Location:491 → 550

PAP_assoc; Cid1 family poly A polymerase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

215277802..215288869

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063271613.1 → XP_063127683.1 speckle targeted PIP5K1A-regulated poly(A) polymerase isoform X1

UniProtKB/TrEMBL

A0A8I6ADU1
XM_063271615.1 → XP_063127685.1 speckle targeted PIP5K1A-regulated poly(A) polymerase isoform X2

UniProtKB/TrEMBL

A0A8I6ADU1
XM_063271617.1 → XP_063127687.1 speckle targeted PIP5K1A-regulated poly(A) polymerase isoform X3

UniProtKB/TrEMBL

A0A8I6ADU1