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    Prrc1 proline-rich coiled-coil 1 [ Mus musculus (house mouse) ]

    Gene ID: 73137, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Prrc1provided by MGI
    Official Full Name
    proline-rich coiled-coil 1provided by MGI
    Primary source
    MGI:MGI:1916106
    See related
    Ensembl:ENSMUSG00000024594 AllianceGenome:MGI:1916106
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1190002C06Rik; 2310058D16Rik; 3110038B19Rik; 9430085A19Rik
    Summary
    Predicted to enable protein kinase A regulatory subunit binding activity. Predicted to be involved in epithelial structure maintenance. Predicted to be located in Golgi apparatus. Predicted to be active in cytoplasm. Is expressed in Meckel's cartilage; chondrocranium; and olfactory epithelium. Orthologous to human PRRC1 (proline rich coiled-coil 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 24.1), limb E14.5 (RPKM 22.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Prrc1 in Genome Data Viewer
    Location:
    18 D3; 18 31.92 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (57487805..57526028)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (57354733..57392956)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 4, regulatory subunit 1 pseudogene Neighboring gene predicted gene, 57649 Neighboring gene predicted gene, 19500 Neighboring gene predicted gene, 34982

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Rearrangement of the Protein Phosphatase 1 Interactome During Heart Failure Progression. Chiang DY, et al. Circulation, 2018 Oct 9. PMID 29669786, Free PMC Article
    2. Protein-protein interaction panel using mouse full-length cDNAs. Suzuki H, et al. Genome Res, 2001 Oct. PMID 11591653, Free PMC Article
    3. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein kinase A regulatory subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in epithelial structure maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    protein PRRC1
    Names
    proline-rich and coiled-coil-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028447.3 → NP_082723.2  protein PRRC1

      See identical proteins and their annotated locations for NP_082723.2

      Status: VALIDATED

      Source sequence(s)
      AC122117, AK143537, BY292301
      Consensus CDS
      CCDS37825.1
      UniProtKB/Swiss-Prot
      Q3UPH1, Q91YT1
      Related
      ENSMUSP00000025490.9, ENSMUST00000025490.10
      Conserved Domains (2) summary
      PHA03247
      Location:10 → 208
      PHA03247; large tegument protein UL36; Provisional
      cl00866
      Location:261 → 374
      NTPase_I-T; Protein of unknown function DUF84

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      57487805..57526028
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526289.2 → XP_006526352.1  protein PRRC1 isoform X1

      See identical proteins and their annotated locations for XP_006526352.1

      UniProtKB/Swiss-Prot
      Q3UPH1, Q91YT1
      Conserved Domains (2) summary
      PHA03247
      Location:10 → 208
      PHA03247; large tegument protein UL36; Provisional
      cl00866
      Location:261 → 374
      NTPase_I-T; Protein of unknown function DUF84

    2. XM_006526288.3 → XP_006526351.1  protein PRRC1 isoform X1

      See identical proteins and their annotated locations for XP_006526351.1

      UniProtKB/Swiss-Prot
      Q3UPH1, Q91YT1
      Conserved Domains (2) summary
      PHA03247
      Location:10 → 208
      PHA03247; large tegument protein UL36; Provisional
      cl00866
      Location:261 → 374
      NTPase_I-T; Protein of unknown function DUF84

    3. XM_030250618.1 → XP_030106478.1  protein PRRC1 isoform X1

      UniProtKB/Swiss-Prot
      Q3UPH1, Q91YT1
      Conserved Domains (2) summary
      PHA03247
      Location:10 → 208
      PHA03247; large tegument protein UL36; Provisional
      cl00866
      Location:261 → 374
      NTPase_I-T; Protein of unknown function DUF84

    4. XM_030250617.1 → XP_030106477.1  protein PRRC1 isoform X1

      UniProtKB/Swiss-Prot
      Q3UPH1, Q91YT1
      Conserved Domains (2) summary
      PHA03247
      Location:10 → 208
      PHA03247; large tegument protein UL36; Provisional
      cl00866
      Location:261 → 374
      NTPase_I-T; Protein of unknown function DUF84
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UPH1.1 GenPept UniProtKB/Swiss-Prot:Q3UPH1

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