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    Klra9 killer cell lectin-like receptor subfamily A, member 9 [ Mus musculus (house mouse) ]

    Gene ID: 16640, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Klra9provided by MGI
    Official Full Name
    killer cell lectin-like receptor subfamily A, member 9provided by MGI
    Primary source
    MGI:MGI:1321153
    See related
    Ensembl:ENSMUSG00000033024 AllianceGenome:MGI:1321153
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ly49I; LY49I1
    Summary
    Predicted to enable signaling receptor activity. Predicted to be involved in regulation of signal transduction. Predicted to be located in plasma membrane. Predicted to be active in cell surface. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Klra9 in Genome Data Viewer
    Location:
    6 F3; 6 63.44 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (130155589..130171337, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (130178626..130194374, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene killer cell lectin-like receptor subfamily A, member 14, pseudogene Neighboring gene predicted gene, 23552 Neighboring gene predicted gene, 52487 Neighboring gene killer cell lectin-like receptor, subfamily A, member 7 Neighboring gene killer cell lectin-like receptor subfamily A, member 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Variable MHC class I engagement by Ly49 natural killer cell receptors demonstrated by the crystal structure of Ly49C bound to H-2K(b). Dam J, et al. Nat Immunol, 2003 Dec. PMID 14595439
    2. B6 strain Ly49I inhibitory gene expression on T cells in FVB.Ly49IB6 transgenic mice fails to prevent normal T cell functions. Morris MA, et al. J Immunol, 2002 Oct 1. PMID 12244158
    3. Analysis of Ly49 gene transcripts in mature NK cells supports a role for the Pro1 element in gene activation, not gene expression. McCullen MV, et al. Genes Immun, 2016 Sep. PMID 27467282, Free PMC Article
    4. Glycosylation contributes to variability in expression of murine cytomegalovirus m157 and enhances stability of interaction with the NK-cell receptor Ly49H. Guseva NV, et al. Eur J Immunol, 2010 Sep. PMID 20662096, Free PMC Article
    5. Molecular architecture of the major histocompatibility complex class I-binding site of Ly49 natural killer cell receptors. Deng L, et al. J Biol Chem, 2008 Jun 13. PMID 18426793, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Clearance of lung cancer is facilitated by up-regulation of NKG2D, NKp46, and other activating receptors upon exposure to environmental MHCI. Surface expression of the inhibitory receptor Ly49C/I, on the other hand, is down-regulated upon exposure to tumor-bearing tissue.
      Title: Modulation of NKG2D, NKp46, and Ly49C/I facilitates natural killer cell-mediated control of lung cancer.
    2. NK cells' own MHC-I significantly masks the Ly49A and Ly49C, but not the Ly49I receptor. Nevertheless, Ly49I was partly masked on transfected tumor cells, suggesting that the structure of Ly49I is compatible in principal with cis binding of MHC-I.
      Title: Interactions of Ly49 family receptors with MHC class I ligands in trans and cis.
    3. mouse cytomegalovirus(MCMV) m157 protein binds to Ly49I
      Title: Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors.
    4. Crystal structure of the Ly49I natural killer cell receptor reveals variability in dimerization mode within the Ly49 family.
      Title: Crystal structure of the Ly49I natural killer cell receptor reveals variability in dimerization mode within the Ly49 family.
    5. Contrary to findings in other inhibitory LY49 transgenic systems, no defects in T cell function are observed in Ly49I transgenic FVB mice.
      Title: B6 strain Ly49I inhibitory gene expression on T cells in FVB.Ly49IB6 transgenic mice fails to prevent normal T cell functions.
    6. The repertoire of inhibitory Ly49 receptors may be formed under the influenced of Fyn-dependent NK cell activation as well as the respective MHC class I environment.
      Title: A role for the src family kinase Fyn in NK cell activation and the formation of the repertoire of Ly49 receptors.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    killer cell lectin-like receptor subfamily A, member 9
    Names
    Ly49I receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010651.3 → NP_034781.2  killer cell lectin-like receptor subfamily A, member 9

      See identical proteins and their annotated locations for NP_034781.2

      Status: VALIDATED

      Source sequence(s)
      AC090127, U49865
      Consensus CDS
      CCDS39667.1
      UniProtKB/TrEMBL
      Q2TJJ8, Q9JHN9
      Related
      ENSMUSP00000071485.3, ENSMUST00000071554.3
      Conserved Domains (2) summary
      cd03593
      Location:145 → 259
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
      pfam08391
      Location:40 → 157
      Ly49; Ly49-like protein, N-terminal region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      130155589..130171337 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241235.1 → XP_011239537.1  killer cell lectin-like receptor subfamily A, member 9 isoform X1

      See identical proteins and their annotated locations for XP_011239537.1

      UniProtKB/TrEMBL
      Q2TJJ8, Q9JHN9
      Conserved Domains (2) summary
      cd03593
      Location:145 → 259
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
      pfam08391
      Location:40 → 157
      Ly49; Ly49-like protein, N-terminal region

    2. XM_011241233.1 → XP_011239535.1  killer cell lectin-like receptor subfamily A, member 9 isoform X1

      See identical proteins and their annotated locations for XP_011239535.1

      UniProtKB/TrEMBL
      Q2TJJ8, Q9JHN9
      Conserved Domains (2) summary
      cd03593
      Location:145 → 259
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
      pfam08391
      Location:40 → 157
      Ly49; Ly49-like protein, N-terminal region

    3. XM_036165891.1 → XP_036021784.1  killer cell lectin-like receptor subfamily A, member 9 isoform X1

      UniProtKB/TrEMBL
      Q2TJJ8, Q9JHN9
      Conserved Domains (2) summary
      cd03593
      Location:145 → 259
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
      pfam08391
      Location:40 → 157
      Ly49; Ly49-like protein, N-terminal region

    4. XM_030255202.1 → XP_030111062.1  killer cell lectin-like receptor subfamily A, member 9 isoform X1

      UniProtKB/TrEMBL
      Q2TJJ8, Q9JHN9
      Conserved Domains (2) summary
      cd03593
      Location:145 → 259
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
      pfam08391
      Location:40 → 157
      Ly49; Ly49-like protein, N-terminal region
    Nucleotide Protein Strain
    Heading Accession and Version

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