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    UGT3A2 UDP glycosyltransferase family 3 member A2 [ Homo sapiens (human) ]

    Gene ID: 167127, updated on 27-Nov-2024

    Summary

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    Official Symbol
    UGT3A2provided by HGNC
    Official Full Name
    UDP glycosyltransferase family 3 member A2provided by HGNC
    Primary source
    HGNC:HGNC:27266
    See related
    Ensembl:ENSG00000168671 MIM:616384; AllianceGenome:HGNC:27266
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables UDP-glycosyltransferase activity. Acts upstream of or within cellular response to genistein. Predicted to be located in membrane. Predicted to be part of UDP-N-acetylglucosamine transferase complex. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in skin (RPKM 4.5), bone marrow (RPKM 1.8) and 5 other tissues See more
    Orthologs
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    Genomic context

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    See UGT3A2 in Genome Data Viewer
    Location:
    5p13.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (36035021..36066882, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (36283283..36315165, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (36035123..36066984, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene CAPSL divergent transcript Neighboring gene UDP glycosyltransferase family 3 member A1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:36040865-36041365 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:36060047-36060547 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22475 Neighboring gene LMBR1 domain containing 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:36151273-36152256 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22476 Neighboring gene RNA, U6 small nuclear 1305, pseudogene Neighboring gene microRNA 580 Neighboring gene S-phase kinase associated protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of residues that confer sugar selectivity to UDP-glycosyltransferase 3A (UGT3A) enzymes. Meech R, et al. J Biol Chem, 2012 Jul 13. PMID 22621930, Free PMC Article
    2. Rab11-FIP1 and Rab11-FIP5 Regulate pIgR/pIgA Transcytosis through TRIM21-Mediated Polyubiquitination. Fan X, et al. Int J Mol Sci, 2021 Sep 28. PMID 34638806, Free PMC Article
    3. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. Zhang X, et al. Carcinogenesis, 2010 Dec. PMID 20819778, Free PMC Article
    4. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. Otsuki T, et al. DNA Res, 2005. PMID 16303743
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Clark HF, et al. Genome Res, 2003 Oct. PMID 12975309, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A phenylalanine (Phe-391) in UGT3A2 favors UDP-Glc use.
      Title: Identification of residues that confer sugar selectivity to UDP-glycosyltransferase 3A (UGT3A) enzymes.
    2. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
      Title: MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC119426, MGC119429

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables UDP-glycosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glucuronosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to genistein IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of UDP-N-acetylglucosamine transferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    UDP-glucuronosyltransferase 3A2
    Names
    UDP glycosyltransferase 3 family, polypeptide A2
    UDPGT 3A2
    NP_001161788.1
    NP_777574.2
    XP_011512290.1
    XP_054207854.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168316.2 → NP_001161788.1  UDP-glucuronosyltransferase 3A2 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This variant encodes isoform 2 which is shorter than isoform 1.
      Source sequence(s)
      AC016612, AK300751, AY358416
      Consensus CDS
      CCDS54842.1
      UniProtKB/Swiss-Prot
      Q3SY77
      Related
      ENSP00000427404.1, ENST00000513300.5
      Conserved Domains (1) summary
      cl10013
      Location:49 → 457
      Glycosyltransferase_GTB-type; glycosyltransferase family 1 and related proteins with GTB topology

    2. NM_174914.4 → NP_777574.2  UDP-glucuronosyltransferase 3A2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_777574.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC016612, AK075383, AY358416
      Consensus CDS
      CCDS3914.1
      UniProtKB/Swiss-Prot
      B4DUQ7, E9PFK7, Q3SY77, Q6UXC4, Q8NBP2
      Related
      ENSP00000282507.3, ENST00000282507.8
      Conserved Domains (1) summary
      cl10013
      Location:23 → 491
      Glycosyltransferase_GTB-type; glycosyltransferase family 1 and related proteins with GTB topology

    RNA

    1. NR_031764.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC016612, AK075383, AK303154, AY358416
      Related
      ENST00000504685.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      36035021..36066882 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011513988.2 → XP_011512290.1  UDP-glucuronosyltransferase 3A2 isoform X1

      Conserved Domains (2) summary
      PHA03392
      Location:162 → 517
      egt; ecdysteroid UDP-glucosyltransferase; Provisional
      pfam00201
      Location:23 → 518
      UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      36283283..36315165 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054351879.1 → XP_054207854.1  UDP-glucuronosyltransferase 3A2 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3SY77.1 GenPept UniProtKB/Swiss-Prot:Q3SY77

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