TIMP2 TIMP metallopeptidase inhibitor 2 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: TIMP2provided by VGNC
Official Full Name: TIMP metallopeptidase inhibitor 2provided by VGNC
Primary source: VGNC:VGNC:35871
See related: BGD:BT11357; Ensembl:ENSBTAG00000010899
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	19	NC_037346.1 (53460835..53512593)

Chromosome 19 - NC_037346.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate the involvement of PKC-alpha in proMMP-2 activation and inhibition of TIMP-2 expression by NF-kappaB-MT1-MMP-dependent and -independent pathway.
Title: Role of PKC-α in NF-κB-MT1-MMP-mediated activation of proMMP-2 by TNF-α in pulmonary artery smooth muscle cells.
A differential pattern of matrix metalloproteinase-2 and Tissue inhibitor metalloproteinase-2 was observed in cow uteri with adenomyosis.
Title: Differential immunohistochemical expression of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 in cow uteri with adenomyosis during follicular phase.
MMP-14, MMP-2 and TIMP-2 are co-localized in the fetal compartment and therefore could influence the timely release of fetal membranes in cattle.
Title: Expression of matrix metalloproteinase (MMP)-2, MMP-14 and tissue inhibitor of matrix metalloproteinase (TIMP)-2 during bovine placentation and at term with or without placental retention.
Results describe distinct changes in expression of MMP2, MMP14, and the metallopeptidase inhibitor TIMP2 between different phases of the estrous cycle indicating an endocrine regulation.
Title: Bovine endometrial metallopeptidases MMP14 and MMP2 and the metallopeptidase inhibitor TIMP2 participate in maternal preparation of pregnancy.
legumain and TIMP-2 mRNAs were up-regulated in the endometrium during the luteal phase of the oestrous cycle and during early pregnancy
Title: Bovine endometrial legumain and TIMP-2 regulation in response to presence of a conceptus.
Results suggest that MMP-2, MMP-9, and TIMP-2 mRNAs are expressed in bovine placentomes during the gestational and postpartum periods and that these enzymes, in conjunction with steroidogenic enzymes, mediate fetal membrane detachment after parturition.
Title: Quantitative analysis of messenger RNA expression of matrix metalloproteinases (MMP-2 and MMP-9), tissue inhibitor-2 of matrix metalloproteinases (TIMP-2), and steroidogenic enzymes in bovine placentomes during gestation and postpartum.
We have solved the 2.0 A crystal structure of the complex between the catalytic domain of human MMP-13 (cdMMP-13) and bovine TIMP-2.
Title: Flexibility and variability of TIMP binding: X-ray structure of the complex between collagenase-3/MMP-13 and TIMP-2.
the different temporal expression patterns of TIMP-1 and TIMP-2 suggest that TIMP-1 may be important for luteal formation and development, while TIMP-2 may play significant roles during luteal development and maintenance
Title: Temporal and spatial expression of tissue inhibitors of metalloproteinases 1 and 2 (TIMP-1 and -2) in the bovine corpus luteum.
Identification, purification and partial characterization of timp-2 in bovine pulmonary artery smooth muscle
Title: Identification, purification and partial characterization of tissue inhibitor of matrix metalloproteinase-2 in bovine pulmonary artery smooth muscle.
TIMP-2 has a role in the pericyte-induced stabilization of newly formed vascular networks that are predisposed to undergo regression and reveal specific molecular targets of the inhibitors regulating these events.
Title: Coregulation of vascular tube stabilization by endothelial cell TIMP-2 and pericyte TIMP-3.

Submit: New GeneRIF Correction See all GeneRIFs (13)

General gene information

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Markers

Timp2 (e-PCR), detects polymorphism
- UniSTS:265761

Timp2 (e-PCR), detects polymorphism
- UniSTS:532066

Timp2 (e-PCR), detects polymorphism
- UniSTS:532067

BARC0054 (e-PCR)
- UniSTS:255333

Timp2 (e-PCR), detects polymorphism
- UniSTS:532070

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables metalloendopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protease binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of endopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of membrane protein ectodomain proteolysis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to cytokine	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to hormone	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular matrix	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: metalloproteinase inhibitor 2

Names: TIMP-2; collagenase inhibitor; tissue inhibitor of metalloproteinases 2; tissue inhibitor of mettaloproteinase 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174472.4 → NP_776897.2 metalloproteinase inhibitor 2 precursor

See identical proteins and their annotated locations for NP_776897.2

Status: PROVISIONAL

Source sequence(s)

BC102710

UniProtKB/Swiss-Prot

P16368, Q3SZU3, Q9TVB1

Related

ENSBTAP00000014476.5, ENSBTAT00000014476.5

Conserved Domains (1) summary

cd03585
Location:27 → 209

NTR_TIMP; NTR domain, TIMP subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by ...