Ftcd formiminotransferase cyclodeaminase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ftcdprovided by MGI
Official Full Name: formiminotransferase cyclodeaminaseprovided by MGI
Primary source: MGI:MGI:1339962
See related: Ensembl:ENSMUSG00000001155 AllianceGenome:MGI:1339962
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable formimidoyltetrahydrofolate cyclodeaminase activity; glutamate formimidoyltransferase activity; and microtubule binding activity. Predicted to be involved in cytoskeleton organization. Predicted to act upstream of or within L-histidine catabolic process. Located in Golgi apparatus. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and respiratory system. Human ortholog(s) of this gene implicated in glutamate formiminotransferase deficiency. Orthologous to human FTCD (formimidoyltransferase cyclodeaminase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in liver adult (RPKM 178.1), liver E18 (RPKM 58.0) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 39.25 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (76411482..76426172)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (76575648..76590338)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Exosome-Related FTCD Facilitates M1 Macrophage Polarization and Impacts the Prognosis of Hepatocellular Carcinoma.
Title: Exosome-Related FTCD Facilitates M1 Macrophage Polarization and Impacts the Prognosis of Hepatocellular Carcinoma.
Autoreactive B cell response against formiminotransferase-cyclodeaminase correlated with disease activity, possibly linking B-cell autoreactivity and AIH pathogenesis
Title: Forkhead box p3+ regulatory T cell underlies male resistance to experimental type 2 autoimmune hepatitis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (9)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:259080 (e-PCR)
- UniSTS:259080

Ftcd (e-PCR), detects polymorphism
- UniSTS:259080

Ftcd (e-PCR), detects polymorphism
- UniSTS:259611

NoName (e-PCR)
- UniSTS:236384

Ftcd (e-PCR), detects polymorphism
- UniSTS:526038

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables folic acid binding	IEA Inferred from Electronic Annotation more info
enables formimidoyltetrahydrofolate cyclodeaminase activity	ISO Inferred from Sequence Orthology more info
enables formimidoyltetrahydrofolate cyclodeaminase activity	TAS Traceable Author Statement more info	PubMed
enables glutamate formimidoyltransferase activity	ISO Inferred from Sequence Orthology more info
enables glutamate formimidoyltransferase activity	TAS Traceable Author Statement more info	PubMed
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within L-histidine catabolic process	TAS Traceable Author Statement more info	PubMed
involved_in L-histidine catabolic process to glutamate and formamide	IEA Inferred from Electronic Annotation more info
involved_in L-histidine catabolic process to glutamate and formate	IEA Inferred from Electronic Annotation more info
involved_in cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in tetrahydrofolate interconversion	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in centriole	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum-Golgi intermediate compartment	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum-Golgi intermediate compartment	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in smooth endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in smooth endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: formimidoyltransferase-cyclodeaminase

Names: glutamate formiminotransferase

NP_543121.1

EC 2.1.2.5

EC 4.3.1.4

XP_006513278.1

EC 2.1.2.5

EC 4.3.1.4

XP_006513279.1

EC 2.1.2.5

EC 4.3.1.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_080845.2 → NP_543121.1 formimidoyltransferase-cyclodeaminase

See identical proteins and their annotated locations for NP_543121.1

Status: VALIDATED

Source sequence(s)

AK165414, BB610765, CB949427, CD297973

Consensus CDS

CCDS23950.1

UniProtKB/Swiss-Prot

Q91XD4

Related

ENSMUSP00000001183.8, ENSMUST00000001183.8

Conserved Domains (2) summary

TIGR02024
Location:1 → 328

FtcD; glutamate formiminotransferase

pfam04961
Location:340 → 519

FTCD_C; Formiminotransferase-cyclodeaminase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

76411482..76426172

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006513216.3 → XP_006513279.1 formimidoyltransferase-cyclodeaminase isoform X2

Conserved Domains (3) summary

pfam02971
Location:32 → 175

FTCD; Formiminotransferase domain

pfam04961
Location:190 → 363

FTCD_C; Formiminotransferase-cyclodeaminase

cl26845
Location:4 → 30

FTCD_N; Formiminotransferase domain, N-terminal subdomain
XM_006513215.3 → XP_006513278.1 formimidoyltransferase-cyclodeaminase isoform X1

Conserved Domains (2) summary

pfam04961
Location:323 → 496

FTCD_C; Formiminotransferase-cyclodeaminase

cl26845
Location:2 → 312

FTCD_N; Formiminotransferase domain, N-terminal subdomain