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    Sgk3 serum/glucocorticoid regulated kinase 3 [ Mus musculus (house mouse) ]

    Gene ID: 170755, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sgk3provided by MGI
    Official Full Name
    serum/glucocorticoid regulated kinase 3provided by MGI
    Primary source
    MGI:MGI:2182368
    See related
    Ensembl:ENSMUSG00000025915 AllianceGenome:MGI:2182368
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    fy; fz; Cisk; 2510015P22Rik; A330005P07Rik
    Summary
    Enables molecular adaptor activity and protein serine/threonine kinase activity. Acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand. Located in cytoplasmic vesicle. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and sensory organ. Orthologous to human C8orf44-SGK3 (C8orf44-SGK3 readthrough) and SGK3 (serum/glucocorticoid regulated kinase family member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in placenta adult (RPKM 7.0), liver E14 (RPKM 4.9) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sgk3 in Genome Data Viewer
    Location:
    1 A2; 1 2.08 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (9868355..9972795)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (9798130..9902570)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene valosin containing protein (p97)/p47 complex interacting protein 1 Neighboring gene RIKEN cDNA 1700034P13 gene Neighboring gene STARR-seq mESC enhancer starr_00169 Neighboring gene STARR-seq mESC enhancer starr_00171 Neighboring gene predicted gene, 39590 Neighboring gene translation machinery-associated protein 7 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7715 Neighboring gene predicted pseudogene 6195 Neighboring gene STARR-seq mESC enhancer starr_00172 Neighboring gene mitochondrial ribosomal protein S36 pseudogene Neighboring gene minichromosome maintenance domain containing 2 Neighboring gene small nucleolar RNA, C/D box 87 Neighboring gene small nucleolar RNA host gene 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. SGK3 Sensitivity of Voltage Gated K+ Channel Kv1.5 (KCNA5). Ahmed M, et al. Cell Physiol Biochem, 2016. PMID 26824455
    2. Decreased bone density and increased phosphaturia in gene-targeted mice lacking functional serum- and glucocorticoid-inducible kinase 3. Bhandaru M, et al. Kidney Int, 2011 Jul. PMID 21451460, Free PMC Article
    3. Blunted IgE-mediated activation of mast cells in mice lacking the serum- and glucocorticoid-inducible kinase SGK3. Zemtsova IM, et al. Am J Physiol Cell Physiol, 2010 Nov. PMID 20686074, Free PMC Article
    4. Mutations in the serum/glucocorticoid regulated kinase 3 (Sgk3) are responsible for the mouse fuzzy (fz) hair phenotype. Campagna DR, et al. J Invest Dermatol, 2008 Mar. PMID 17914447
    5. SGK3 regulates Ca(2+) entry and migration of dendritic cells. Schmid E, et al. Cell Physiol Biochem, 2012. PMID 23171960, Free PMC Article

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SGK3 deficiency in macrophages suppresses angiotensin II-induced cardiac remodeling via regulating Ndufa13-mediated mitochondrial oxidative stress.
      Title: SGK3 deficiency in macrophages suppresses angiotensin II-induced cardiac remodeling via regulating Ndufa13-mediated mitochondrial oxidative stress.
    2. SGK3 promotes vascular calcification via Pit-1 in chronic kidney disease.
      Title: SGK3 promotes vascular calcification via Pit-1 in chronic kidney disease.
    3. MicroRNA-92a-3p Regulates Retinal Angiogenesis by Targeting SGK3 in Vascular Endothelial Cells.
      Title: MicroRNA-92a-3p Regulates Retinal Angiogenesis by Targeting SGK3 in Vascular Endothelial Cells.
    4. The SGK3-triggered ubiquitin-proteasome degradation of podocalyxin and ezrin in podocytes was associated with the stability of the PC/ezrin complex.
      Title: The SGK3-triggered ubiquitin-proteasome degradation of podocalyxin (PC) and ezrin in podocytes was associated with the stability of the PC/ezrin complex.
    5. Study data from human hepatocellular carcinoma (HCC) liver samples, human HCC cells, and Sgk3 knockout mice model suggest that SGK3 plays a role in transducing helical domain mutant PIK3CA signaling during liver tumor development.
      Title: Functional role of SGK3 in PI3K/Pten driven liver tumor development.
    6. Taken together, these data strongly suggest that SGK3 plays a significant role in regulating podocyte function, likely by controlling the expression and activity of GSK3.
      Title: Lack of serum- and glucocorticoid-inducible kinase 3 leads to podocyte dysfunction.
    7. SGK1 and SGK3 are expressed in multiple microglial cell lines. SGK1 and SGK3 may play an important role in regulating microglial viability and inflammatory responses.
      Title: Serum- and glucocorticoid-inducible kinases in microglia.
    8. SGK3 is a positive regulator of KCNA5, which is at least partially effective by abrogating the effect of Nedd4-2.
      Title: SGK3 Sensitivity of Voltage Gated K+ Channel Kv1.5 (KCNA5).
    9. SGK3 contributes to the regulation of store-operated calcium entry into and migration of dendritic cells.
      Title: SGK3 regulates Ca(2+) entry and migration of dendritic cells.
    10. SGK3 plays a previously unappreciated role in glucose homeostasis, likely through direct effects within pancreatic beta-cells, to stimulate proliferation and insulin release
      Title: Novel role for SGK3 in glucose homeostasis revealed in SGK3/Akt2 double-null mice.
    Submit: New GeneRIF Correction See all GeneRIFs (26)

    Phenotypes

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    Associated conditions

    Description Tests
    fuzzy
    GeneReviews: Not available

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular adaptor activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in recycling endosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase Sgk3
    Names
    cytokine-independent survival kinase
    NP_001032848.1
    NP_573483.1
    NP_808215.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037759.1 → NP_001032848.1  serine/threonine-protein kinase Sgk3

      See identical proteins and their annotated locations for NP_001032848.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC102570, AC158928, AK030314
      Consensus CDS
      CCDS14816.1
      UniProtKB/Swiss-Prot
      Q3UAY2, Q9ERE3
      UniProtKB/TrEMBL
      Q3U9B2
      Related
      ENSMUSP00000127462.2, ENSMUST00000171265.8
      Conserved Domains (3) summary
      cd06870
      Location:12 → 120
      PX_CISK; The phosphoinositide binding Phox Homology Domain of Cytokine-Independent Survival Kinase
      smart00220
      Location:162 → 419
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05604
      Location:165 → 490
      STKc_SGK3; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 3

    2. NM_133220.2 → NP_573483.1  serine/threonine-protein kinase Sgk3

      See identical proteins and their annotated locations for NP_573483.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC102570, AC158928, AK031133, BB856423
      Consensus CDS
      CCDS14816.1
      UniProtKB/Swiss-Prot
      Q3UAY2, Q9ERE3
      UniProtKB/TrEMBL
      Q3U9B2
      Related
      ENSMUSP00000126861.2, ENSMUST00000168907.8
      Conserved Domains (3) summary
      cd06870
      Location:12 → 120
      PX_CISK; The phosphoinositide binding Phox Homology Domain of Cytokine-Independent Survival Kinase
      smart00220
      Location:162 → 419
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05604
      Location:165 → 490
      STKc_SGK3; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 3

    3. NM_177547.3 → NP_808215.2  serine/threonine-protein kinase Sgk3

      See identical proteins and their annotated locations for NP_808215.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC102570, AC158928, AK031133, BB856423
      Consensus CDS
      CCDS14816.1
      UniProtKB/Swiss-Prot
      Q3UAY2, Q9ERE3
      UniProtKB/TrEMBL
      Q3U9B2
      Related
      ENSMUSP00000130078.2, ENSMUST00000166384.8
      Conserved Domains (3) summary
      cd06870
      Location:12 → 120
      PX_CISK; The phosphoinositide binding Phox Homology Domain of Cytokine-Independent Survival Kinase
      smart00220
      Location:162 → 419
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05604
      Location:165 → 490
      STKc_SGK3; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      9868355..9972795
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ERE3.1 GenPept UniProtKB/Swiss-Prot:Q9ERE3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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