Vdac1 voltage-dependent anion channel 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Vdac1provided by MGI
Official Full Name: voltage-dependent anion channel 1provided by MGI
Primary source: MGI:MGI:106919
See related: Ensembl:ENSMUSG00000020402 AllianceGenome:MGI:106919
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Vdac5; mVDAC1; mVDAC5
Summary: This gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membrane and may regulate mitochondrial functions. This protein also forms channels in the plasma membrane and may be involved in transmembrane electron transport. Multiple pseudogenes of this gene are found on chromosomes 1, 2, 3, 6, 8, 9, and X. [provided by RefSeq, Sep 2015]
Expression: Ubiquitous expression in heart adult (RPKM 147.4), kidney adult (RPKM 93.8) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B1.3; 11 31.86 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (52251905..52280224)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (52360851..52389397)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

E3 ubiquitin ligase TRIM31 alleviates dopaminergic neurodegeneration by promoting proteasomal degradation of VDAC1 in Parkinson's Disease model.
Title: E3 ubiquitin ligase TRIM31 alleviates dopaminergic neurodegeneration by promoting proteasomal degradation of VDAC1 in Parkinson's Disease model.
Phosphoglycerate mutase 5 aggravates alcoholic liver disease through disrupting VDAC-1-dependent mitochondrial integrity.
Title: Phosphoglycerate mutase 5 aggravates alcoholic liver disease through disrupting VDAC-1-dependent mitochondrial integrity.
LncRNA H19 inhibition impairs endoplasmic reticulum-mitochondria contact in hepatic cells and augments gluconeogenesis by increasing VDAC1 levels.
Title: LncRNA H19 inhibition impairs endoplasmic reticulum-mitochondria contact in hepatic cells and augments gluconeogenesis by increasing VDAC1 levels.
Identification and validation of voltage-dependent anion channel 1-related genes and immune cell infiltration in diabetic nephropathy.
Title: Identification and validation of voltage-dependent anion channel 1-related genes and immune cell infiltration in diabetic nephropathy.
Voltage-dependent anion channel 1 (VDAC1) overexpression alleviates cardiac fibroblast activation in cardiac fibrosis via regulating fatty acid metabolism.
Title: Voltage-dependent anion channel 1 (VDAC1) overexpression alleviates cardiac fibroblast activation in cardiac fibrosis via regulating fatty acid metabolism.
[VDAC1 participates in house dust mite-induced asthmatic airway inflammation in mice by inducing ferroptosis of airway epithelial cells].
Title: [VDAC1 participates in house dust mite-induced asthmatic airway inflammation in mice by inducing ferroptosis of airway epithelial cells].
DYNLT1 promotes mitochondrial metabolism to fuel breast cancer development by inhibiting ubiquitination degradation of VDAC1.
Title: DYNLT1 promotes mitochondrial metabolism to fuel breast cancer development by inhibiting ubiquitination degradation of VDAC1.
SAMHD1 Attenuates Acute Inflammation by Maintaining Mitochondrial Function in Macrophages via Interaction with VDAC1.
Title: SAMHD1 Attenuates Acute Inflammation by Maintaining Mitochondrial Function in Macrophages via Interaction with VDAC1.
Upregulation of the ERRgamma-VDAC1 axis underlies the molecular pathogenesis of pancreatitis.
Title: Upregulation of the ERRγ-VDAC1 axis underlies the molecular pathogenesis of pancreatitis.
MCU Upregulation Overactivates Mitophagy by Promoting VDAC1 Dimerization and Ubiquitination in the Hepatotoxicity of Cadmium.
Title: MCU Upregulation Overactivates Mitophagy by Promoting VDAC1 Dimerization and Ubiquitination in the Hepatotoxicity of Cadmium.

Submit: New GeneRIF Correction See all GeneRIFs (59)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Gene trapped (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

U30840 (e-PCR)
- UniSTS:180190

MARC_23885-23886:1031761371:1 (e-PCR)
- UniSTS:268790

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ceramide binding	IEA Inferred from Electronic Annotation more info
enables ceramide binding	ISO Inferred from Sequence Orthology more info
enables cholesterol binding	IEA Inferred from Electronic Annotation more info
enables cholesterol binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables monoatomic anion channel activity	ISO Inferred from Sequence Orthology more info
enables oxysterol binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphatidylcholine binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylcholine binding	ISO Inferred from Sequence Orthology more info
enables porin activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info
enables voltage-gated monoatomic anion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated monoatomic anion channel activity	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated monoatomic anion channel activity	ISO Inferred from Sequence Orthology more info	PubMed
enables voltage-gated monoatomic ion channel activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in acetyl-CoA biosynthetic process from pyruvate	ISO Inferred from Sequence Orthology more info	PubMed
involved_in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within behavioral fear response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium import into the mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid transport	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in monoatomic anion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic anion transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of calcium import into the mitochondrion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of calcium import into the mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of reactive oxygen species metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron-neuron synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of type 2 mitophagy	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of type 2 mitophagy	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitophagy	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	HDA more info	PubMed
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial nucleoid	IEA Inferred from Electronic Annotation more info
located_in mitochondrial nucleoid	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info	PubMed
located_in mitochondrial outer membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of mitochondrial permeability transition pore complex	ISO Inferred from Sequence Orthology more info
part_of mitochondrial permeability transition pore complex	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed
located_in myelin sheath	HDA more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic active zone membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: non-selective voltage-gated ion channel VDAC1

Names: outer mitochondrial membrane protein porin 1; plasmalemmal porin; voltage-dependent anion-selective channel protein 1; voltage-dependent anion-selective channel protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001362693.2 → NP_001349622.1 non-selective voltage-gated ion channel VDAC1 isoform 1

Status: VALIDATED

Source sequence(s)

AL645589, AL713864

Conserved Domains (1) summary

cd07306
Location:86 → 364

Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane
NM_001400986.1 → NP_001387915.1 non-selective voltage-gated ion channel VDAC1 isoform 3

Status: VALIDATED

Source sequence(s)

AL645589, AL713864
NM_001400987.1 → NP_001387916.1 non-selective voltage-gated ion channel VDAC1 isoform 4

Status: VALIDATED

Source sequence(s)

AL645589, AL713864
NM_001400988.1 → NP_001387917.1 non-selective voltage-gated ion channel VDAC1 isoform 2

Status: VALIDATED

Source sequence(s)

AL645589, AL713864
NM_001400989.1 → NP_001387918.1 non-selective voltage-gated ion channel VDAC1 isoform 2

Status: VALIDATED

Source sequence(s)

AL645589, AL713864
NM_011694.7 → NP_035824.1 non-selective voltage-gated ion channel VDAC1 isoform 2

See identical proteins and their annotated locations for NP_035824.1

Status: VALIDATED

Source sequence(s)

AL645589, AL713864

Consensus CDS

CCDS24671.1

UniProtKB/TrEMBL

Q3THL7, Q3TIG8, Q3U6K8

Related

ENSMUSP00000099819.2, ENSMUST00000102758.8

Conserved Domains (1) summary

cd07306
Location:4 → 282

Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane