Aldob aldolase B, fructose-bisphosphate [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Aldobprovided by MGI
Official Full Name: aldolase B, fructose-bisphosphateprovided by MGI
Primary source: MGI:MGI:87995
See related: Ensembl:ENSMUSG00000028307 AllianceGenome:MGI:87995
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Aldo2; Aldo-2
Summary: This gene encodes a subunit of the homotetrameric enzyme aldolase B, an isozyme of the class I fructose 1,6-bisphosphate aldolase enzyme. This enzyme catalyzes the conversion of fructose 1,6-bisphosphate to dihydroxyacetone phosphate and glyceraldehyde 3-phosphate. Homozygous knockout mice for this gene exhibit liver damage and death following fructose ingestion. A pseudogene of this gene has been identified in the genome. [provided by RefSeq, Aug 2015]
Expression: Biased expression in kidney adult (RPKM 1344.8), liver adult (RPKM 757.5) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 B1; 4 26.57 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (49535993..49549546, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (49535993..49549546, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hepatic glucokinase regulatory protein and carbohydrate response element binding protein attenuation reduce de novo lipogenesis but do not mitigate intrahepatic triglyceride accumulation in Aldob deficiency.
Title: Hepatic glucokinase regulatory protein and carbohydrate response element binding protein attenuation reduce de novo lipogenesis but do not mitigate intrahepatic triglyceride accumulation in Aldob deficiency.
Fructose-1,6-Bisphosphate Aldolase B Depletion Promotes Hepatocellular Carcinogenesis Through Activating Insulin Receptor Signaling and Lipogenesis.
Title: Fructose-1,6-Bisphosphate Aldolase B Depletion Promotes Hepatocellular Carcinogenesis Through Activating Insulin Receptor Signaling and Lipogenesis.
NKCC2 surface expression in mammalian cells is shown to be downregulated by a novel interaction with aldolase B
Title: NKCC2 surface expression in mammalian cells: down-regulation by novel interaction with aldolase B.
characterization of the aldolase B gene enhancer
Title: In vivo functional characterization of the aldolase B gene enhancer.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Aldob (e-PCR), detects polymorphism
- UniSTS:506725

RH94455 (e-PCR)
- UniSTS:119703

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATPase binding	IEA Inferred from Electronic Annotation more info
enables ATPase binding	ISO Inferred from Sequence Orthology more info
enables cytoskeletal protein binding	IEA Inferred from Electronic Annotation more info
enables cytoskeletal protein binding	ISO Inferred from Sequence Orthology more info
enables fructose binding	IEA Inferred from Electronic Annotation more info
enables fructose binding	ISO Inferred from Sequence Orthology more info
enables fructose-1-phosphate aldolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables fructose-1-phosphate aldolase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables fructose-1-phosphate aldolase activity	ISO Inferred from Sequence Orthology more info
enables fructose-1-phosphate aldolase activity	ISS Inferred from Sequence or Structural Similarity more info
enables fructose-bisphosphate aldolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables fructose-bisphosphate aldolase activity	IDA Inferred from Direct Assay more info	PubMed
enables fructose-bisphosphate aldolase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables fructose-bisphosphate aldolase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	IEA Inferred from Electronic Annotation more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylcholine binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in NADH oxidation	IEA Inferred from Electronic Annotation more info
involved_in NADH oxidation	ISO Inferred from Sequence Orthology more info
involved_in fructose 1,6-bisphosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fructose 1,6-bisphosphate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in fructose 1,6-bisphosphate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in fructose catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in fructose catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate	IC Inferred by Curator more info	PubMed
involved_in fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fructose metabolic process	ISO Inferred from Sequence Orthology more info
involved_in gluconeogenesis	IEA Inferred from Electronic Annotation more info
involved_in glycolytic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycolytic process	ISO Inferred from Sequence Orthology more info
involved_in glycolytic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within glycolytic process through fructose-1-phosphate	IC Inferred by Curator more info	PubMed
acts_upstream_of_or_within glycolytic process through fructose-6-phosphate	IC Inferred by Curator more info	PubMed
involved_in negative regulation of pentose-phosphate shunt	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of pentose-phosphate shunt	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ATP-dependent activity	ISO Inferred from Sequence Orthology more info
involved_in response to peptide hormone	ISO Inferred from Sequence Orthology more info
involved_in response to zinc ion	ISO Inferred from Sequence Orthology more info
involved_in vacuolar proton-transporting V-type ATPase complex assembly	IEA Inferred from Electronic Annotation more info
involved_in vacuolar proton-transporting V-type ATPase complex assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in centriolar satellite	IEA Inferred from Electronic Annotation more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in microtubule organizing center	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in rough endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in smooth endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: fructose-bisphosphate aldolase B

Names: liver-type aldolase

NP_659152.1

EC 4.1.2.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.