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    Atp5mc3 ATP synthase membrane subunit c locus 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114630, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Atp5mc3provided by RGD
    Official Full Name
    ATP synthase membrane subunit c locus 3provided by RGD
    Primary source
    RGD:620052
    See related
    EnsemblRapid:ENSRNOG00000001596 AllianceGenome:RGD:620052
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Atp5g3
    Summary
    Enables ligand-gated channel activity. Involved in several processes, including pore complex assembly; response to (R)-carnitine; and response to muscle stretch. Part of cation channel complex. Human ortholog(s) of this gene implicated in early-onset dystonia and/or spastic paraplegia. Orthologous to human ATP5MC3 (ATP synthase membrane subunit c locus 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 6718.7), Muscle (RPKM 4018.1) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Atp5mc3 in Genome Data Viewer
    Location:
    3q23
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (79218014..79220664, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (58810535..58813185, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (60811218..60813903, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486116 Neighboring gene activating transcription factor 2 Neighboring gene uncharacterized LOC120101572 Neighboring gene NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1-like Neighboring gene uncharacterized LOC134478830

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Investigation of differentially expressed genes in the ventricular myocardium of senescent rats. Ishihata A, et al. Ann N Y Acad Sci, 2006 May. PMID 16803979
    2. Identification of differentially expressed genes induced in the rat brain by acetyl-L-carnitine as evidenced by suppression subtractive hybridisation. Traina G, et al. Brain Res Mol Brain Res, 2004 Dec 6. PMID 15548429
    3. Differentially expressed genes and morphological changes during lengthened immobilization in rat soleus muscle. Kim JW, et al. Differentiation, 2007 Feb. PMID 17316384
    4. Batten disease and the control of the Fo subunit c pore by cGMP and calcium. McGeoch JE, et al. Eur J Paediatr Neurol, 2001. PMID 11588987
    5. Rat mitochondrial ATP synthase ATP5G3: cloning and upregulation in pancreas after chronic ethanol feeding. Li HS, et al. Physiol Genomics, 2001 Jul 17. PMID 11459924

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ligand-gated channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proton transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in pore complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proton motive force-driven ATP synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proton motive force-driven ATP synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to (R)-carnitine IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to ethanol IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to muscle stretch IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of cation channel complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    part_of proton-transporting ATP synthase complex, coupling factor F(o) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proton-transporting ATP synthase complex, coupling factor F(o) IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ATP synthase F(0) complex subunit C3, mitochondrial
    Names
    ATP synthase lipid-binding protein, mitochondrial
    ATP synthase proteolipid P3
    ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9)
    ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9)
    ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)
    ATPase protein 9
    ATPase subunit c

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001361400.1 → NP_001348329.1  ATP synthase F(0) complex subunit C3, mitochondrial precursor

      Status: VALIDATED

      Source sequence(s)
      FN800719, JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6AAH2, F7EW45, Q499S2
      Related
      ENSRNOP00000055032.3, ENSRNOT00000058234.5
      Conserved Domains (1) summary
      MTH00222
      Location:67 → 141
      ATP9; ATP synthase F0 subunit 9; Provisional

    2. NM_001361401.1 → NP_001348330.1  ATP synthase F(0) complex subunit C3, mitochondrial precursor

      Status: VALIDATED

      Source sequence(s)
      FM058126, JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6AAH2, F7EW45, Q499S2
      Conserved Domains (1) summary
      MTH00222
      Location:67 → 141
      ATP9; ATP synthase F0 subunit 9; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      79218014..79220664 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_053756.1: Suppressed sequence

      Description
      NM_053756.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q71S46.1 GenPept UniProtKB/Swiss-Prot:Q71S46

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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