Pga3 pepsinogen A3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pga3provided by RGD
Official Full Name: pepsinogen A3provided by RGD
Primary source: RGD:621573
See related: EnsemblRapid:ENSRNOG00000047279 AllianceGenome:RGD:621573
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pepf; Pga5
Summary: Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in proteolysis. Orthologous to several human genes including PGA5 (pepsinogen A5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 4.3), Kidney (RPKM 3.2) and 3 other tissues See more
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Genomic context

Location:: 1q43

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (216741935..216752067, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (207317021..207327156, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	Unplaced Scaffold	NW_007906915.1 (96134..106813, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables aspartic-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aspartic-type endopeptidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: pepsinogen A3

Names: pepsin F-like; pepsinogen 5, group I (pepsinogen A); pepsinogen A5; pepsinogen F protein

NP_068521.1

EC 3.4.23.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021753.1 → NP_068521.1 pepsinogen A3 precursor

See identical proteins and their annotated locations for NP_068521.1

Status: PROVISIONAL

Source sequence(s)

AJ251687

UniProtKB/TrEMBL

A0A0G2JT02, A0A0G2K8A8, Q9JJX2

Related

ENSRNOP00000066518.1, ENSRNOT00000072343.4

Conserved Domains (2) summary

pfam07966
Location:16 → 44

A1_Propeptide; A1 Propeptide

cl11403
Location:64 → 385

pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases