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    Mcts1 MCTS1, re-initiation and release factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 302500, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mcts1provided by RGD
    Official Full Name
    MCTS1, re-initiation and release factorprovided by RGD
    Primary source
    RGD:1566390
    See related
    EnsemblRapid:ENSRNOG00000002563 AllianceGenome:RGD:1566390
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA cap binding activity; ribosomal small subunit binding activity; and translation factor activity, non-nucleic acid binding. Predicted to be involved in IRES-dependent viral translational initiation; cytoplasmic translational initiation; and ribosome disassembly. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human MCTS1 (MCTS1 re-initiation and release factor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 102.1), Thymus (RPKM 99.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mcts1 in Genome Data Viewer
    Location:
    Xq35
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (122215602..122228101)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (117350723..117362504)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (124894269..124906129)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene ragulator complex protein LAMTOR5-like Neighboring gene uncharacterized LOC134484034 Neighboring gene cullin 4B Neighboring gene C1GALT1-specific chaperone 1 Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Maresin Conjugates in Tissue Regeneration 1 improves alveolar fluid clearance by up-regulating alveolar ENaC, Na, K-ATPase in lipopolysaccharide-induced acute lung injury. Han J, et al. J Cell Mol Med, 2020 Apr. PMID 32160403, Free PMC Article
    2. Activities of Ligatin and MCT-1/DENR in eukaryotic translation initiation and ribosomal recycling. Skabkin MA, et al. Genes Dev, 2010 Aug 15. PMID 20713520, Free PMC Article
    3. Identification of novel proteins associated with both alpha-synuclein and DJ-1. Jin J, et al. Mol Cell Proteomics, 2007 May. PMID 16854843
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Maresin Conjugates in Tissue Regeneration 1 improves alveolar fluid clearance by up-regulating alveolar ENaC, Na, K-ATPase in lipopolysaccharide-induced acute lung injury.
      Title: Maresin Conjugates in Tissue Regeneration 1 improves alveolar fluid clearance by up-regulating alveolar ENaC, Na, K-ATPase in lipopolysaccharide-induced acute lung injury.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC112904

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA cap binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA cap binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA cap binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ribosomal small subunit binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosomal small subunit binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribosomal small subunit binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables translation factor activity, non-nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation factor activity, non-nucleic acid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables translation factor activity, non-nucleic acid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in IRES-dependent viral translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in IRES-dependent viral translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in formation of translation preinitiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in formation of translation preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in formation of translation preinitiation complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome disassembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome disassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosome disassembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in translation reinitiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation reinitiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in translation reinitiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    malignant T-cell-amplified sequence 1
    Names
    MCT-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044237.2 → NP_001037702.1  malignant T-cell-amplified sequence 1 isoform 2

      See identical proteins and their annotated locations for NP_001037702.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/Swiss-Prot
      Q4G009
      UniProtKB/TrEMBL
      A0A8I6ADP8, A6JMK9
      Related
      ENSRNOP00000061717.1, ENSRNOT00000066677.3
      Conserved Domains (2) summary
      cd11609
      Location:5 → 81
      MCT1_N; N-terminal domain of multiple copies T cell malignancies 1 and related proteins
      cd21155
      Location:81 → 176
      PUA_MCTS-1-like; PUA RNA-binding domain of malignant T cell-amplified sequence 1 and related proteins

    2. NM_001434002.1 → NP_001420931.1  malignant T-cell-amplified sequence 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A0G2K724, A0A8I6ADP8, A6JMK7

    3. NM_001434003.1 → NP_001420932.1  malignant T-cell-amplified sequence 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A6JMK8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      122215602..122228101
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006257488.5 → XP_006257550.1  malignant T-cell-amplified sequence 1 isoform X1

      Related
      ENSRNOP00000074032.1, ENSRNOT00000080894.3
      Conserved Domains (2) summary
      cd11609
      Location:4 → 80
      MCT1_N; N-terminal domain of multiple copies T cell malignancies 1 and related proteins
      cd21155
      Location:80 → 175
      PUA_MCTS-1-like; PUA RNA-binding domain of malignant T cell-amplified sequence 1 and related proteins

    2. XM_039099623.2 → XP_038955551.1  malignant T-cell-amplified sequence 1 isoform X2

      Conserved Domains (2) summary
      pfam17832
      Location:5 → 38
      Pre-PUA; Pre-PUA-like domain
      cd21155
      Location:29 → 124
      PUA_MCTS-1-like; PUA RNA-binding domain of malignant T cell-amplified sequence 1 and related proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4G009.1 GenPept UniProtKB/Swiss-Prot:Q4G009

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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