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    Ahsa2 activator of HSP90 ATPase homolog 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305577, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Ahsa2provided by RGD
    Official Full Name
    activator of HSP90 ATPase homolog 2provided by RGD
    Primary source
    RGD:1307171
    See related
    EnsemblRapid:ENSRNOG00000052142 AllianceGenome:RGD:1307171
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ATPase activator activity. Predicted to be involved in protein folding. Predicted to be active in cytosol. Orthologous to human AHSA2P (activator of HSP90 ATPase homolog 2, pseudogene). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Lung (RPKM 122.8), Thymus (RPKM 122.1) and 9 other tissues See more
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    Genomic context

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    See Ahsa2 in Genome Data Viewer
    Location:
    14q22
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (101677447..101688706, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (97476304..97485725, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (108262795..108274000, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene small ribosomal subunit protein eS24-like Neighboring gene ubiquitin specific peptidase 34 Neighboring gene telomerase RNA component interacting Rnase like 1 Neighboring gene uncharacterized LOC108352815 Neighboring gene similar to human chromosome 2 open reading frame 74 Neighboring gene deoxycytidine kinase, pseudogene 1 Neighboring gene SANT and BTB domain regulator of CSR

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-folding chaperone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    activator of 90 kDa heat shock protein ATPase homolog 2
    Names
    AHA1, activator of heat shock protein ATPase 2
    AHA1, activator of heat shock protein ATPase homolog 2
    activator of heat shock protein ATPase homolog 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401431.1 → NP_001388360.1  activator of 90 kDa heat shock protein ATPase homolog 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A0G2K7W5, A0A8I6ACS3
      Related
      ENSRNOP00000074374.1, ENSRNOT00000084642.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      101677447..101688706 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006251541.5 → XP_006251603.1  activator of 90 kDa heat shock protein ATPase homolog 2 isoform X3

      See identical proteins and their annotated locations for XP_006251603.1

      UniProtKB/TrEMBL
      A0A8I6ACS3
      Conserved Domains (2) summary
      cd08892
      Location:154 → 273
      SRPBCC_Aha1; Putative hydrophobic ligand-binding SRPBCC domain of the Hsp90 co-chaperone Aha1 and related proteins
      smart01000
      Location:1 → 110
      Aha1_N; Activator of Hsp90 ATPase, N-terminal

    2. XM_006251539.5 → XP_006251601.1  activator of 90 kDa heat shock protein ATPase homolog 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ACS3
      Related
      ENSRNOP00000091962.2, ENSRNOT00000095424.2
      Conserved Domains (3) summary
      cd08892
      Location:239 → 358
      SRPBCC_Aha1; Putative hydrophobic ligand-binding SRPBCC domain of the Hsp90 co-chaperone Aha1 and related proteins
      smart01000
      Location:67 → 195
      Aha1_N; Activator of Hsp90 ATPase, N-terminal
      COG5580
      Location:20 → 358
      COG5580; Activator of HSP90 ATPase [Posttranslational modification, protein turnover, chaperones]

    3. XM_063273267.1 → XP_063129337.1  activator of 90 kDa heat shock protein ATPase homolog 2 isoform X2

    4. XM_006251542.5 → XP_006251604.1  activator of 90 kDa heat shock protein ATPase homolog 2 isoform X3

      See identical proteins and their annotated locations for XP_006251604.1

      UniProtKB/TrEMBL
      A0A8I6ACS3
      Conserved Domains (2) summary
      cd08892
      Location:154 → 273
      SRPBCC_Aha1; Putative hydrophobic ligand-binding SRPBCC domain of the Hsp90 co-chaperone Aha1 and related proteins
      smart01000
      Location:1 → 110
      Aha1_N; Activator of Hsp90 ATPase, N-terminal

    RNA

    1. XR_005492978.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107241.1: Suppressed sequence

      Description
      NM_001107241.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version

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