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    rusc2 RUN and SH3 domain containing 2 [ Danio rerio (zebrafish) ]

    Gene ID: 556081, updated on 4-Jan-2025

    Summary

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    Official Symbol
    rusc2provided by ZNC
    Official Full Name
    RUN and SH3 domain containing 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060526-131
    See related
    AllianceGenome:ZFIN:ZDB-GENE-060526-131
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch211-250o15.2
    Summary
    Is expressed in central nervous system. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 61. Orthologous to human RUSC2 (RUN and SH3 domain containing 2). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See rusc2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (19301520..19329292)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (18797479..18825492)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene protein unc-13 homolog B Neighboring gene uncharacterized LOC137495512 Neighboring gene ATPase phospholipid transporting 8B5a Neighboring gene uncharacterized LOC103911062 Neighboring gene acetyl-CoA carboxylase beta Neighboring gene forkhead box N4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    AP-4 complex accessory subunit RUSC2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      19301520..19329292
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005165191.5 → XP_005165248.1  AP-4 complex accessory subunit RUSC2 isoform X2

      UniProtKB/TrEMBL
      A0A8M2BCE1
      Conserved Domains (3) summary
      cd11957
      Location:1517 → 1568
      SH3_RUSC2; Src homology 3 domain of RUN and SH3 domain-containing protein 2
      pfam02759
      Location:1010 → 1120
      RUN; RUN domain
      pfam03153
      Location:748 → 924
      TFIIA; Transcription factor IIA, alpha/beta subunit

    2. XM_005165190.5 → XP_005165247.1  AP-4 complex accessory subunit RUSC2 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BCE9
      Conserved Domains (2) summary
      cd11957
      Location:1583 → 1634
      SH3_RUSC2; Src homology 3 domain of RUN and SH3 domain-containing protein 2
      pfam02759
      Location:1076 → 1186
      RUN; RUN domain
    Nucleotide Protein Strain
    Heading Accession and Version

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