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    Lemd2 LEM domain nuclear envelope protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361807, updated on 9-Dec-2024

    Summary

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    Symbol
    Lemd2provided by RGD
    Full Name
    LEM domain nuclear envelope protein 2provided by RGD
    Primary source
    RGD:1305341
    See related
    EnsemblRapid:ENSRNOG00000025864 AllianceGenome:RGD:1305341
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable chromatin DNA binding activity. Predicted to be involved in several processes, including heart formation; negative regulation of signal transduction; and protein localization to chromatin. Predicted to act upstream of or within negative regulation of MAPK cascade and skeletal muscle cell differentiation. Predicted to be located in chromatin; endoplasmic reticulum; and nuclear inner membrane. Human ortholog(s) of this gene implicated in cataract 46 juvenile-onset. Orthologous to human LEMD2 (LEM domain nuclear envelope protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 108.0), Lung (RPKM 97.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lemd2 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (5284275..5298281, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (5282397..5296621, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (5779742..5786213, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene inositol hexakisphosphate kinase 3 Neighboring gene uncharacterized LOC108353257 Neighboring gene uncharacterized LOC120098965 Neighboring gene motilin Neighboring gene uncharacterized LOC102551729

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The inner nuclear membrane protein Lem2 is critical for normal nuclear envelope morphology. Ulbert S, et al. FEBS Lett, 2006 Nov 27. PMID 17097643
    2. LEM2 is a novel MAN1-related inner nuclear membrane protein associated with A-type lamins. Brachner A, et al. J Cell Sci, 2005 Dec 15. PMID 16339967
    3. Overlapping functions of nuclear envelope proteins NET25 (Lem2) and emerin in regulation of extracellular signal-regulated kinase signaling in myoblast differentiation. Huber MD, et al. Mol Cell Biol, 2009 Nov. PMID 19720741, Free PMC Article
    4. Nuclear envelope protein Lem2 is required for mouse development and regulates MAP and AKT kinases. Tapia O, et al. PLoS One, 2015. PMID 25790465, Free PMC Article
    5. LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells. Gu M, et al. Proc Natl Acad Sci U S A, 2017 Mar 14. PMID 28242692, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC112806

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in heart formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neurogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear envelope organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within skeletal muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    LEM domain-containing protein 2
    Names
    LEM domain containing 2
    LEM domain-containing protein 2-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039032.2 → NP_001034121.2  LEM domain-containing protein 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      Related
      ENSRNOP00000102261.1, ENSRNOT00000035819.8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      5284275..5298281 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039098814.2 → XP_038954742.1  LEM domain-containing protein 2 isoform X1

      Conserved Domains (2) summary
      pfam09402
      Location:277 → 504
      MSC; Man1-Src1p-C-terminal domain
      cl02649
      Location:4 → 41
      LEM; LEM (Lap2/Emerin/Man1) domain found in emerin, lamina-associated polypeptide 2 (LAP2), inner nuclear membrane protein Man1 and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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