STRN4 striatin 4 [Homo sapiens (human)] - Gene

Summary

Official Symbol: STRN4provided by HGNC
Official Full Name: striatin 4provided by HGNC
Primary source: HGNC:HGNC:15721
See related: Ensembl:ENSG00000090372 MIM:614767; AllianceGenome:HGNC:15721
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ZIN; PPP2R6C; zinedin
Summary: Enables armadillo repeat domain binding activity; protein phosphatase 2A binding activity; and protein-macromolecule adaptor activity. Involved in negative regulation of hippo signaling. Part of FAR/SIN/STRIPAK complex. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in testis (RPKM 42.4), spleen (RPKM 16.0) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19q13.32

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (46719511..46746450, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (49545101..49572026, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (47222768..47249707, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Epigenetic modifications precede molecular alterations and drive human hepatocarcinogenesis.
Title: Epigenetic modifications precede molecular alterations and drive human hepatocarcinogenesis.
MAP4K Interactome Reveals STRN4 as a Key STRIPAK Complex Component in Hippo Pathway Regulation.
Title: MAP4K Interactome Reveals STRN4 as a Key STRIPAK Complex Component in Hippo Pathway Regulation.
Results showed that depletion of STRN4 suppresses proliferation, migration, invasion and the anchorage-independent growth of cancer cells.
Title: Silencing of STRN4 suppresses the malignant characteristics of cancer cells.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic susceptibility variants for chronic lymphocytic leukemia.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S2921 (e-PCR)
- UniSTS:152074

A006X06 (e-PCR)
- UniSTS:42939

RH11878 (e-PCR)
- UniSTS:61182

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables armadillo repeat domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	NAS Non-traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase 2A binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase 2A binding	IDA Inferred from Direct Assay more info	PubMed
enables protein-containing complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables protein-macromolecule adaptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of hippo signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of modification of postsynaptic structure	IEA Inferred from Electronic Annotation more info
involved_in regulation of signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of FAR/SIN/STRIPAK complex	IBA Inferred from Biological aspect of Ancestor more info
part_of FAR/SIN/STRIPAK complex	IDA Inferred from Direct Assay more info	PubMed
located_in GABA-ergic synapse	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: striatin-4

Names: protein phosphatase 2 regulatory subunit B'''gamma; striatin, calmodulin binding protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039877.2 → NP_001034966.1 striatin-4 isoform 2

See identical proteins and their annotated locations for NP_001034966.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2).

Source sequence(s)

AB209003, AF212940, DA510367

Consensus CDS

CCDS42581.1

UniProtKB/TrEMBL

Q59GV6

Related

ENSP00000375777.1, ENST00000391910.7

Conserved Domains (4) summary

COG2319
Location:423 → 753

WD40; WD40 repeat [General function prediction only]

cd00200
Location:437 → 759

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam08232
Location:64 → 189

Striatin; Striatin family

sd00039
Location:450 → 496

7WD40; WD40 repeat [structural motif]
NM_013403.3 → NP_037535.2 striatin-4 isoform 1

See identical proteins and their annotated locations for NP_037535.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) uses an alternate splice site in the central coding region, compared to variant 2. The resulting isoform (1) lacks an internal 7-aa segment, compared to isoform 2.

Source sequence(s)

AF212940, BC034604, DA510367

Consensus CDS

CCDS12690.1

UniProtKB/Swiss-Prot

A0A024R0V2, B4DQH7, F8VYA6, Q8NE53, Q9NRL3

UniProtKB/TrEMBL

Q59GV6

Related

ENSP00000263280.4, ENST00000263280.11

Conserved Domains (4) summary

COG2319
Location:416 → 746

WD40; WD40 repeat [General function prediction only]

cd00200
Location:430 → 752

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam08232
Location:64 → 189

Striatin; Striatin family

sd00039
Location:443 → 489

7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p14 Primary Assembly

Range

46719511..46746450 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006723172.3 → XP_006723235.1 striatin-4 isoform X2

UniProtKB/TrEMBL

Q59GV6

Conserved Domains (4) summary

COG2319
Location:431 → 761

WD40; WD40 repeat [General function prediction only]

cd00200
Location:445 → 767

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam08232
Location:64 → 204

Striatin; Striatin family

sd00039
Location:458 → 504

7WD40; WD40 repeat [structural motif]
XM_006723171.3 → XP_006723234.1 striatin-4 isoform X1

UniProtKB/TrEMBL

Q59GV6

Conserved Domains (4) summary

COG2319
Location:438 → 768

WD40; WD40 repeat [General function prediction only]

cd00200
Location:452 → 774

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam08232
Location:64 → 204

Striatin; Striatin family

sd00039
Location:465 → 511

7WD40; WD40 repeat [structural motif]
XM_047438714.1 → XP_047294670.1 striatin-4 isoform X5

UniProtKB/TrEMBL

F5GYK2

Related

ENSP00000440901.1, ENST00000539396.5
XM_047438713.1 → XP_047294669.1 striatin-4 isoform X4
XM_047438712.1 → XP_047294668.1 striatin-4 isoform X3
XM_047438715.1 → XP_047294671.1 striatin-4 isoform X6
XM_011526878.2 → XP_011525180.1 striatin-4 isoform X7

Conserved Domains (1) summary

pfam08232
Location:64 → 204

Striatin; Striatin family
XM_017026719.2 → XP_016882208.1 striatin-4 isoform X8