Sumo3 small ubiquitin-like modifier 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sumo3provided by MGI
Official Full Name: small ubiquitin-like modifier 3provided by MGI
Primary source: MGI:MGI:1336201
See related: Ensembl:ENSMUSG00000020265 AllianceGenome:MGI:1336201
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SMT3A; SUMO-3; Smt3h1; D10Ertd345e; 2810014B19Rik
Summary: This gene encodes a member of the small ubiquitin-like modifier family. The encoded protein may regulate a variety of proteins in many pathways via a post-translational modification, known as SUMOylation. This activity may play a role in a wide variety of cellular processes, including nuclear transport, DNA replication and repair, mitosis, transcriptional regulation, and signal transduction. Disruption of some of these processes has been associated with cerebral ischemia, neural dysfunction, and heart disease. A pseudogene of this gene has been defined on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 48.9), placenta adult (RPKM 46.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 39.72 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (77441931..77454165)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (77606097..77618331)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Aberrant SUMO2/3 modification of RUNX1 upon SENP1 inhibition is linked to the development of diabetic retinopathy in mice.
Title: Aberrant SUMO2/3 modification of RUNX1 upon SENP1 inhibition is linked to the development of diabetic retinopathy in mice.
The requirement of SUMO2/3 for SENP2 mediated extraembryonic and embryonic development.
Title: The requirement of SUMO2/3 for SENP2 mediated extraembryonic and embryonic development.
integrity is required for PLK1 localization with SUMO-1 but not with SUMO-2/3. Inhibition of SUMOylation disrupts proper meiotic bipolar spindle organization and spindle-kinetochore attachment.
Title: Temporal and SUMO-specific SUMOylation contribute to the dynamics of Polo-like kinase 1 (PLK1) and spindle integrity during mouse oocyte meiosis.
a regulatory role of ZNF451-1 in fine-tuning physiological PML levels
Title: The SUMO2/3 specific E3 ligase ZNF451-1 regulates PML stability.
Results indicate that a functional SUMO1-3 expression is essential for emotionality and cognition
Title: Neuron-specific Sumo1-3 knockdown in mice impairs episodic and fear memories.
Expression levels and not functional differences between SUMO2 and SUMO3 are critical for normal embryogenesis.
Title: SUMO2 is essential while SUMO3 is dispensable for mouse embryonic development.
The purpose of this study was to perform a comprehensive analysis of the SUMO3-modified proteome regulated by brain ischemia using a novel SUMO transgenic mouse.
Title: Small ubiquitin-like modifier 3-modified proteome regulated by brain ischemia in novel small ubiquitin-like modifier transgenic mice: putative protective proteins/pathways.
Stress-induced phosphorylation of Thr486 in c-Myb by p38 mitogen-activated protein kinases attenuates conjugation of SUMO-2/3.
Title: Stress-induced phosphorylation of Thr486 in c-Myb by p38 mitogen-activated protein kinases attenuates conjugation of SUMO-2/3.
post-ischemic activation of SUMO2/3 conjugation may define the fate of neurons exposed to a transient interruption of blood supply
Title: Transient ischemia induces massive nuclear accumulation of SUMO2/3-conjugated proteins in spinal cord neurons.
These results suggest that increased Sumo3 in the hippocampus may be correlated with spatial learning ability in old C57BL/6 mice
Title: Correlation of increased hippocampal Sumo3 with spatial learning ability in old C57BL/6 mice.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Sumo3 (e-PCR), detects polymorphism
- UniSTS:259144

NoName (e-PCR)
- UniSTS:493140

AW121497 (e-PCR)
- UniSTS:164444

RH127006 (e-PCR)
- UniSTS:167011

D10Jhu54 (e-PCR), detects polymorphism
- UniSTS:158710

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SUMO transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tag activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-like protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of DNA binding	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein localization to nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in protein sumoylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein sumoylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein sumoylation	ISO Inferred from Sequence Orthology more info
involved_in protein sumoylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of protein localization to nucleus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in PML body	ISO Inferred from Sequence Orthology more info
located_in PML body	ISS Inferred from Sequence or Structural Similarity more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic cytosol	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: small ubiquitin-related modifier 3

Names: SMT3 suppressor of mif two 3 homolog 3; ubiquitin-like protein SMT3A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001301671.1 → NP_001288600.1 small ubiquitin-related modifier 3 isoform 2

See identical proteins and their annotated locations for NP_001288600.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (2) is the same length as isoform 1, but contains a distinct N-terminus.

Source sequence(s)

AK148306, CJ143013, CJ159246, CJ187500

Consensus CDS

CCDS78843.1

UniProtKB/Swiss-Prot

Q9Z172

Related

ENSMUSP00000097136.6, ENSMUST00000099538.6

Conserved Domains (1) summary

cd01763
Location:8 → 92

Sumo; Small ubiquitin-related modifier (SUMO)
NM_001301672.1 → NP_001288601.1 small ubiquitin-related modifier 3 isoform 3

See identical proteins and their annotated locations for NP_001288601.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.

Source sequence(s)

AC153864, AK148306, CJ069985

Consensus CDS

CCDS78841.1

UniProtKB/TrEMBL

G3UWX9

Related

ENSMUSP00000133466.2, ENSMUST00000141228.9

Conserved Domains (2) summary

cd01763
Location:7 → 78

Sumo; Small ubiquitin-related modifier (SUMO)

smart00213
Location:17 → 74

UBQ; Ubiquitin homologues
NM_001301673.1 → NP_001288602.1 small ubiquitin-related modifier 3 isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a longer protein (isoform 4), compared to isoform 1.

Source sequence(s)

AC153864, AK148306, BY085566

Consensus CDS

CCDS78842.1

UniProtKB/TrEMBL

G3UZA7

Related

ENSMUSP00000134416.2, ENSMUST00000129492.8

Conserved Domains (2) summary

cd01763
Location:9 → 95

Sumo; Small ubiquitin-related modifier (SUMO)

smart00213
Location:20 → 88

UBQ; Ubiquitin homologues
NM_019929.4 → NP_064313.1 small ubiquitin-related modifier 3 isoform 1 precursor

See identical proteins and their annotated locations for NP_064313.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes isoform 1.

Source sequence(s)

AC153864, AK148306, CJ069985

Consensus CDS

CCDS23958.1

UniProtKB/Swiss-Prot

Q14C17, Q3TBL9, Q3UDI5, Q9Z172

Related

ENSMUSP00000020501.9, ENSMUST00000020501.15

Conserved Domains (1) summary

cd01763
Location:7 → 92

Sumo; Small ubiquitin-related modifier (SUMO)

RNA

NR_125903.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (6) lacks several exons and uses an alternate 5'-terminal exon, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.

Source sequence(s)

AA105565, AK148306
NR_125904.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (5) contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC153864, AK148306, CJ069985, CK619326