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    Cd55 CD55 molecule (Cromer blood group) [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64036, updated on 3-Dec-2024

    Summary

    Official Symbol
    Cd55provided by RGD
    Official Full Name
    CD55 molecule (Cromer blood group)provided by RGD
    Primary source
    RGD:620651
    See related
    EnsemblRapid:ENSRNOG00000003927 AllianceGenome:RGD:620651
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Daf; Daf1
    Summary
    Enables enzyme inhibitor activity. Involved in several processes, including maternal process involved in parturition; negative regulation of complement activation; and response to peptide hormone. Located in apical plasma membrane. Used to study neuroblastoma and proteinuria. Human ortholog(s) of this gene implicated in prostate cancer and protein-losing enteropathy. Orthologous to human CD55 (CD55 molecule (Cromer blood group)). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 104.8), Lung (RPKM 66.1) and 8 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cd55 in Genome Data Viewer
    Location:
    13q13
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (44409574..44438913, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (41857242..41885966, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (47125156..47153557, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene thrombospondin type 1 domain containing 7B Neighboring gene uncharacterized LOC134481489 Neighboring gene mitochondrial ribosomal protein L30, pseudogene 2 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene zona pellucida 3 receptor

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables enzyme inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables lipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables virus receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in maternal process involved in parturition IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in negative regulation of complement activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of complement activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of CD4-positive, alpha-beta T cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of CD4-positive, alpha-beta T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of T cell cytokine production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of complement activation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of complement activation, classical pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of complement-dependent cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of lipopolysaccharide-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to peptide hormone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in spermatogenesis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in symbiont entry into host cell IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sperm midpiece ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    complement decay-accelerating factor
    Names
    CD55 antigen
    CD55 molecule, decay accelerating factor for complement
    decay accelarating factor 1
    decay accelerating factor 1
    decay accelerating factor GPI-form
    decay-accelarating factor
    glycosylphophatidylinositol-anchored form

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022269.2NP_071605.2  complement decay-accelerating factor precursor

      See identical proteins and their annotated locations for NP_071605.2

      Status: VALIDATED

      Source sequence(s)
      BC061869, CB610207
      UniProtKB/TrEMBL
      A0A0G2QC50, A0A9K3Y778, G3V6H8, Q9QUN6, Q9Z0M0
      Related
      ENSRNOP00000005284.7, ENSRNOT00000005284.8
      Conserved Domains (2) summary
      cd00033
      Location:225284
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      pfam00084
      Location:98158
      Sushi; Sushi repeat (SCR repeat)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      44409574..44438913 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272578.1XP_063128648.1  complement decay-accelerating factor isoform X5

      UniProtKB/TrEMBL
      A9CMA5
    2. XM_063272577.1XP_063128647.1  complement decay-accelerating factor isoform X3

      UniProtKB/TrEMBL
      Q9QUN6
      Related
      ENSRNOP00000079102.2, ENSRNOT00000097302.2
    3. XM_063272579.1XP_063128649.1  complement decay-accelerating factor isoform X8

      UniProtKB/TrEMBL
      A6IBX9
    4. XM_017598924.3XP_017454413.1  complement decay-accelerating factor isoform X10

      UniProtKB/TrEMBL
      A9CMA5
    5. XM_006249723.5XP_006249785.1  complement decay-accelerating factor isoform X9

      UniProtKB/TrEMBL
      Q9QUN6
      Conserved Domains (2) summary
      cd00033
      Location:225284
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      pfam00084
      Location:98158
      Sushi; Sushi repeat (SCR repeat)
    6. XM_017598923.3XP_017454412.1  complement decay-accelerating factor isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZMB7, A6IBX8, Q9QUN6
      Conserved Domains (2) summary
      cd00033
      Location:225284
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      pfam00084
      Location:98158
      Sushi; Sushi repeat (SCR repeat)
    7. XM_039091062.2XP_038946990.1  complement decay-accelerating factor isoform X6

      UniProtKB/TrEMBL
      Q9QUT3
      Conserved Domains (2) summary
      cd00033
      Location:3694
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      PHA02927
      Location:94283
      PHA02927; secreted complement-binding protein; Provisional
    8. XM_006249719.5XP_006249781.1  complement decay-accelerating factor isoform X7

      See identical proteins and their annotated locations for XP_006249781.1

      UniProtKB/TrEMBL
      A6IBY0, Q9QUT3
      Conserved Domains (2) summary
      cd00033
      Location:225284
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      pfam00084
      Location:98158
      Sushi; Sushi repeat (SCR repeat)
    9. XM_008769498.4XP_008767720.1  complement decay-accelerating factor isoform X11

      UniProtKB/TrEMBL
      Q9QUT3
      Conserved Domains (2) summary
      cd00033
      Location:225284
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      pfam00084
      Location:98158
      Sushi; Sushi repeat (SCR repeat)
    10. XM_063272576.1XP_063128646.1  complement decay-accelerating factor isoform X1

    11. XM_006249717.5XP_006249779.1  complement decay-accelerating factor isoform X2

      See identical proteins and their annotated locations for XP_006249779.1

      UniProtKB/TrEMBL
      Q9Z0L9
      Conserved Domains (2) summary
      cd00033
      Location:225284
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      pfam00084
      Location:98158
      Sushi; Sushi repeat (SCR repeat)