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    pkp4 plakophilin 4 [ Danio rerio (zebrafish) ]

    Gene ID: 561566, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pkp4provided by ZNC
    Official Full Name
    plakophilin 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-120411-14
    See related
    Ensembl:ENSDARG00000045331 AllianceGenome:ZFIN:ZDB-GENE-120411-14
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable cadherin binding activity. Predicted to be involved in cell-cell adhesion. Predicted to act upstream of or within cell adhesion. Predicted to be active in several cellular components, including adherens junction; nucleus; and plasma membrane. Orthologous to human PKP4 (plakophilin 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See pkp4 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (12200352..12295833, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (11965492..12061290, complement)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene WD repeat, sterile alpha motif and U-box domain containing 1 Neighboring gene tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1a Neighboring gene si:dkey-276j7.1 Neighboring gene si:dkey-276j7.2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Proteolysis regulates cardiomyocyte maturation and tissue integration. Fukuda R, et al. Nat Commun, 2017 Feb 17. PMID 28211472, Free PMC Article
    2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cadherin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in animal organ development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    plakophilin-4
    Names
    unm_sa1487

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      12200352..12295833 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017356584.3 → XP_017212073.1  plakophilin-4 isoform X6

      UniProtKB/TrEMBL
      A0A8M6YZN9, A0A8M9Q6L4, E7EXI3
      Related
      ENSDARP00000128634.1, ENSDART00000155685.2

    2. XM_068221907.1 → XP_068078008.1  plakophilin-4 isoform X2

      UniProtKB/TrEMBL
      A0A8M9Q6L4

    3. XM_684979.10 → XP_690071.3  plakophilin-4 isoform X3

      UniProtKB/TrEMBL
      A0A2R8QAD2, A0A8M9Q6L4, A0A8N7TB01
      Related
      ENSDARP00000151456.1, ENSDART00000189980.1
      Conserved Domains (4) summary
      cd00020
      Location:469 → 591
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam06136
      Location:105 → 252
      DUF966; Domain of unknown function (DUF966)
      pfam13646
      Location:506 → 580
      HEAT_2; HEAT repeats
      sd00043
      Location:477 → 502
      ARM; armadillo repeat [structural motif]

    4. XM_068221906.1 → XP_068078007.1  plakophilin-4 isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q6L4

    5. XM_068221908.1 → XP_068078009.1  plakophilin-4 isoform X4

      UniProtKB/TrEMBL
      A0A8M9Q6L4
      Related
      ENSDARP00000156646.1, ENSDART00000180473.1

    6. XM_068221910.1 → XP_068078011.1  plakophilin-4 isoform X5

      UniProtKB/TrEMBL
      A0A8M6Z166
      Related
      ENSDARP00000145966.1, ENSDART00000187321.1
    Nucleotide Protein
    Heading Accession and Version

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