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    Tmep Transmembrane endosomal protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38185, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmepprovided by FlyBase
    Official Full Name
    Transmembrane endosomal proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035236
    Locus tag
    Dmel_CG12004
    See related
    AllianceGenome:FB:FBgn0035236
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:fe3A8; CG12004; Dmel\CG12004
    Summary
    Predicted to enable carbohydrate binding activity and transmembrane transporter activity. Involved in defense response to fungus and synaptic target recognition. Predicted to be active in membrane. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval midgut; embryonic/larval midgut primordium; and posterior endoderm. Orthologous to several human genes including TMEM184B (transmembrane protein 184B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tmep in Genome Data Viewer
    Location:
    62A6-62A6; 3-0.5 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1569181..1576330)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1569181..1576330)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Peroxin 10 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Putative Drosophila TMEM184B Ortholog Tmep Ensures Proper Locomotion by Restraining Ectopic Firing at the Neuromuscular Junction. Cho TS, et al. Mol Neurobiol, 2022 Apr. PMID 35107803, Free PMC Article
    2. A nerve-wracking buzz: lessons from Drosophila models of peripheral neuropathy and axon degeneration. Bhattacharya MRC. Front Aging Neurosci, 2023. PMID 37614471, Free PMC Article
    3. Lpt, trr, and Hcf regulate histone mono- and dimethylation that are essential for Drosophila heart development. Huang W, et al. Dev Biol, 2022 Oct. PMID 35853502, Free PMC Article
    4. Genomic basis of aging and life-history evolution in Drosophila melanogaster. Remolina SC, et al. Evolution, 2012 Nov. PMID 23106705, Free PMC Article
    5. Identification and functional analysis of antifungal immune response genes in Drosophila. Jin LH, et al. PLoS Pathog, 2008 Oct 3. PMID 18833296, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables carbohydrate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic target recognition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane endosomal protein
    Names
    CG12004-PA
    CG12004-PB
    CG12004-PC
    CG12004-PD
    Tmep-PA
    Tmep-PB
    Tmep-PC
    Tmep-PD
    anon-fast-evolving-3A8

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1569181..1576330
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299970.1 → NP_001286899.1  transmembrane endosomal protein, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286899.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1A714
      Conserved Domains (1) summary
      pfam03619
      Location:66 → 339
      Solute_trans_a; Organic solute transporter Ostalpha

    2. NM_001104004.2 → NP_001097474.1  transmembrane endosomal protein, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097474.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1A714
      Conserved Domains (1) summary
      pfam03619
      Location:66 → 339
      Solute_trans_a; Organic solute transporter Ostalpha

    3. NM_139370.4 → NP_647627.1  transmembrane endosomal protein, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647627.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960F6, Q9W0D4
      Related
      FBpp0072628
      Conserved Domains (1) summary
      pfam03619
      Location:66 → 339
      Solute_trans_a; Organic solute transporter Ostalpha

    4. NM_167897.2 → NP_728633.1  transmembrane endosomal protein, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728633.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960F6, Q9W0D4
      Related
      FBpp0072629
      Conserved Domains (1) summary
      pfam03619
      Location:66 → 339
      Solute_trans_a; Organic solute transporter Ostalpha
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1A714 A1A714
    Q960F6 Q960F6

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