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    nolo no long nerve cord [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35424, updated on 9-Dec-2024

    Summary

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    Official Symbol
    noloprovided by FlyBase
    Official Full Name
    no long nerve cordprovided by FlyBase
    Primary source
    FLYBASE:FBgn0051619
    Locus tag
    Dmel_CG31619
    See related
    AllianceGenome:FB:FBgn0051619
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13236; CG2122; CG2131; CG31619; CT6940; Dmel\CG31619
    Summary
    Involved in ventral cord development. Is expressed in several structures, including Bolwig organ primordium; CNS glial cell; VL fascicle; ganglia; and gut section. Orthologous to human ADAMTSL1 (ADAMTS like 1) and ADAMTSL3 (ADAMTS like 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See nolo in Genome Data Viewer
    Location:
    39F1-39F3; 2-54 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21684106..21729051)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21684106..21729051)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR46066 Neighboring gene uncharacterized protein Neighboring gene small non-coding RNA 254 Neighboring gene eukaryotic translation elongation factor 2 Neighboring gene steppke Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ovarian transcriptional response to Wolbachia infection in D. melanogaster in the context of between-genotype variation in gene expression. Frantz SI, et al. G3 (Bethesda), 2023 May 2. PMID 36857313, Free PMC Article
    2. Secreted ADAMTS-like proteins as regulators of connective tissue function. Taye N, et al. Am J Physiol Cell Physiol, 2024 Mar 1. PMID 38284126
    3. Chromosome-level organization of the regulatory genome in the Drosophila nervous system. Mohana G, et al. Cell, 2023 Aug 31. PMID 37536338, Free PMC Article
    4. Glia ECM interactions are required to shape the Drosophila nervous system. Meyer S, et al. Mech Dev, 2014 Aug. PMID 24859129
    5. Tau-Mediated Disruption of the Spliceosome Triggers Cryptic RNA Splicing and Neurodegeneration in Alzheimer's Disease. Hsieh YC, et al. Cell Rep, 2019 Oct 8. PMID 31597093, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 21686534-21687088 mobile_element_type = transposon:mariner2{}513
    • Loc: 21689319-21689848 mobile_element_type = transposon:INE-1{}4894
    • Loc: 21698710-21699142 mobile_element_type = transposon:INE-1{}4907
    • Loc: 21699148-21699326 mobile_element_type = transposon:INE-1{}4908
    • Loc: 21703829-21704026 mobile_element_type = transposon:INE-1{}4909
    • Loc: 21705310-21706714 mobile_element_type = transposon:HB{}515
    • Loc: 21706718-21707775 mobile_element_type = transposon:FB{}nolo[FB]
    • Loc: 21707900-21708819 mobile_element_type = transposon:INE-1{}2259
    • Loc: 21708836-21708973 mobile_element_type = transposon:INE-1{}2261
    • Loc: 21710833-21710967 mobile_element_type = transposon:INE-1{}4912
    • Loc: 21711632-21711828 mobile_element_type = transposon:INE-1{}4913
    • Loc: 21715211-21715289 mobile_element_type = transposon:gypsy12{}5498
    • Loc: 21715789-21716113 mobile_element_type = transposon:INE-1{}4915
    • Loc: 21717919-21717969 mobile_element_type = transposon:INE-1{}4923
    • Loc: 21727643-21727769 mobile_element_type = transposon:INE-1{}4926

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in extracellular matrix organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ventral cord development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    no long nerve cord
    Names
    CG31619-PA
    CG31619-PB
    CG31619-PC
    CG31619-PD
    CG31619-PE
    CG31619-PF
    CG31619-PG
    nolo-PA
    nolo-PB
    nolo-PC
    nolo-PD
    nolo-PE
    nolo-PF
    nolo-PG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      21684106..21729051
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259199.2 → NP_001246128.1  no long nerve cord, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246128.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8N3
      Conserved Domains (3) summary
      smart00408
      Location:845 → 902
      IGc2; Immunoglobulin C-2 Type
      smart00209
      Location:78 → 124
      TSP1; Thrombospondin type 1 repeats
      pfam08686
      Location:1355 → 1384
      PLAC; PLAC (protease and lacunin) domain

    2. NM_001299197.1 → NP_001286126.1  no long nerve cord, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286126.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0PTX3, X2JEX4
      Conserved Domains (2) summary
      smart00408
      Location:845 → 902
      IGc2; Immunoglobulin C-2 Type
      smart00209
      Location:78 → 124
      TSP1; Thrombospondin type 1 repeats

    3. NM_165396.3 → NP_724359.1  no long nerve cord, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724359.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V9Q7
      Related
      FBpp0085256
      Conserved Domains (3) summary
      smart00408
      Location:845 → 902
      IGc2; Immunoglobulin C-2 Type
      smart00209
      Location:78 → 124
      TSP1; Thrombospondin type 1 repeats
      pfam08686
      Location:1314 → 1343
      PLAC; PLAC (protease and lacunin) domain

    4. NM_001042909.3 → NP_001036374.1  no long nerve cord, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036374.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8N3
      Conserved Domains (3) summary
      smart00408
      Location:845 → 902
      IGc2; Immunoglobulin C-2 Type
      smart00209
      Location:78 → 124
      TSP1; Thrombospondin type 1 repeats
      pfam08686
      Location:1355 → 1384
      PLAC; PLAC (protease and lacunin) domain

    5. NM_001169569.3 → NP_001163040.1  no long nerve cord, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163040.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JHP3
      Conserved Domains (3) summary
      smart00408
      Location:845 → 902
      IGc2; Immunoglobulin C-2 Type
      smart00209
      Location:78 → 124
      TSP1; Thrombospondin type 1 repeats
      pfam08686
      Location:1349 → 1378
      PLAC; PLAC (protease and lacunin) domain

    6. NM_001299198.1 → NP_001286127.1  no long nerve cord, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286127.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JAM1
      Conserved Domains (3) summary
      smart00408
      Location:838 → 895
      IGc2; Immunoglobulin C-2 Type
      smart00209
      Location:78 → 124
      TSP1; Thrombospondin type 1 repeats
      pfam08686
      Location:1307 → 1336
      PLAC; PLAC (protease and lacunin) domain

    7. NM_165397.3 → NP_724360.1  no long nerve cord, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724360.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0PTX3, Q95R33, Q9V9Q9
      Related
      FBpp0085257
      Conserved Domains (2) summary
      smart00408
      Location:845 → 902
      IGc2; Immunoglobulin C-2 Type
      smart00209
      Location:78 → 124
      TSP1; Thrombospondin type 1 repeats
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JHP3 E1JHP3
    Q0E8N3 Q0E8N3
    Q8MRW9 Q8MRW9
    Q9V9Q7 Q9V9Q7
    Q9V9Q9 Q9V9Q9
    X2JAM1 X2JAM1
    X2JEX4 X2JEX4

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