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    His4:CG31611 histone H4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 318846, updated on 17-Dec-2024

    Summary

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    Official Symbol
    His4:CG31611provided by FlyBase
    Official Full Name
    histone H4provided by FlyBase
    Primary source
    FLYBASE:FBgn0051611
    Locus tag
    Dmel_CG31611
    See related
    AllianceGenome:FB:FBgn0051611
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG31611; Dmel\CG31611; His4
    Summary
    Enables DNA binding activity. Involved in nucleosome assembly. Located in nuclear chromosome. Part of RCAF complex and nucleosome. Is expressed in spermatozoon. Orthologous to several human genes including H4C1 (H4 clustered histone 1); H4C11 (H4 clustered histone 11); and H4C12 (H4 clustered histone 12). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See His4:CG31611 in Genome Data Viewer
    Location:
    39D3-39D3; 2-54 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21424593..21425005, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21424593..21425005, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene histone H2B Neighboring gene histone H2A Neighboring gene small non-coding RNA 430a Neighboring gene histone H3 Neighboring gene histone H1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biotin-tag affinity purification of a centromeric nucleosome assembly complex. Furuyama T, et al. Cell Cycle, 2006 Jun. PMID 16775420
    2. Structural basis for centromere maintenance by Drosophila CENP-A chaperone CAL1. Medina-Pritchard B, et al. EMBO J, 2020 Apr 1. PMID 32134144, Free PMC Article
    3. Hit and run versus long-term activation of PARP-1 by its different domains fine-tunes nuclear processes. Thomas C, et al. Proc Natl Acad Sci U S A, 2019 May 14. PMID 31028139, Free PMC Article
    4. Tetrameric structure of centromeric nucleosomes in interphase Drosophila cells. Dalal Y, et al. PLoS Biol, 2007 Aug. PMID 17676993, Free PMC Article
    5. Concerted regulation of ISWI by an autoinhibitory domain and the H4 N-terminal tail. Ludwigsen J, et al. Elife, 2017 Jan 21. PMID 28109157, Free PMC Article

    See all (76) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A DNA-dependent interaction of MSL3 chromodomain with the H4 lysine20 monomethyl mark, was discovered.
      Title: Corecognition of DNA and a methylated histone tail by the MSL3 chromodomain.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of chromatin IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in nucleosome assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nucleosome assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of RCAF complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nucleosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nucleosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nucleosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    histone H4
    Names
    CG31611-PA
    His4:CG31611-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      21424593..21425005 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165383.3 → NP_724344.1  histone H4 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724344.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V2W8, P84040, Q4AB71, Q4ABE0, Q6AWN1
      UniProtKB/TrEMBL
      A0A0B4KFZ9
      Related
      FBpp0085280
      Conserved Domains (1) summary
      PLN00035
      Location:1 → 103
      PLN00035; histone H4; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P84040.2 P84040

    Gene LinkOut

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