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    CG10602 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35146, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG10602provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032721
    Locus tag
    Dmel_CG10602
    See related
    AllianceGenome:FB:FBgn0032721
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG10602; pepCG10602
    Summary
    Predicted to enable aminopeptidase activity and epoxide hydrolase activity. Predicted to be involved in peptide catabolic process. Predicted to be located in ribosome. Predicted to be active in cytosol. Is expressed in several structures, including adult brain; adult head; embryonic/larval crystal cell; mesoderm; and procrystal cell. Orthologous to human LTA4H (leukotriene A4 hydrolase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG10602 in Genome Data Viewer
    Location:
    37B1-37B1; 2-54 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (18855126..18859248, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (18855126..18859248, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L13 Neighboring gene tailup Neighboring gene mir-4946 stem loop Neighboring gene long non-coding RNA:CR44737

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PI3K/Akt Cooperates with Oncogenic Notch by Inducing Nitric Oxide-Dependent Inflammation. Villegas SN, et al. Cell Rep, 2018 Mar 6. PMID 29514083
    2. Chemical screen reveals small molecules suppressing fragile X premutation rCGG repeat-mediated neurodegeneration in Drosophila. Qurashi A, et al. Hum Mol Genet, 2012 May 1. PMID 22298836, Free PMC Article
    3. A combined computational strategy of sequence and structural analysis predicts the existence of a functional eicosanoid pathway in Drosophila melanogaster. Scarpati M, et al. PLoS One, 2019. PMID 30753230, Free PMC Article
    4. Targets of microRNA regulation in the Drosophila oocyte proteome. Nakahara K, et al. Proc Natl Acad Sci U S A, 2005 Aug 23. PMID 16099838, Free PMC Article
    5. Genetic analysis of dPsa, the Drosophila orthologue of puromycin-sensitive aminopeptidase, suggests redundancy of aminopeptidases. Schulz C, et al. Dev Genes Evol, 2001 Dec. PMID 11819115

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables aminopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables epoxide hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG10602-PC
    CG10602-PD
    CG10602-PF
    NP_609916.5
    NP_724139.1
    NP_724140.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      18855126..18859248 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136072.5 → NP_609916.5  uncharacterized protein Dmel_CG10602, isoform F [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KT44, Q961A0, Q9VJ39, R4GRV7
      Conserved Domains (4) summary
      cd09599
      Location:79 → 520
      M1_LTA4H; Peptidase M1 family contains leukotriene A4 hydrolase
      TIGR02411
      Location:79 → 681
      leuko_A4_hydro; leukotriene A-4 hydrolase/aminopeptidase
      pfam09127
      Location:541 → 680
      Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
      cl00333
      Location:16 → 50
      Ribosomal_L13; Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the ...

    2. NM_165268.3 → NP_724139.1  uncharacterized protein Dmel_CG10602, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724139.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V0U4
      Related
      FBpp0088357
      Conserved Domains (3) summary
      cd09599
      Location:8 → 449
      M1_LTA4H; Peptidase M1 family contains leukotriene A4 hydrolase
      TIGR02411
      Location:8 → 610
      leuko_A4_hydro; leukotriene A-4 hydrolase/aminopeptidase
      pfam09127
      Location:470 → 609
      Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal

    3. NM_165269.3 → NP_724140.1  uncharacterized protein Dmel_CG10602, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724140.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V0U4
      Related
      FBpp0088356
      Conserved Domains (3) summary
      cd09599
      Location:8 → 449
      M1_LTA4H; Peptidase M1 family contains leukotriene A4 hydrolase
      TIGR02411
      Location:8 → 610
      leuko_A4_hydro; leukotriene A-4 hydrolase/aminopeptidase
      pfam09127
      Location:470 → 609
      Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4V0U4 A4V0U4
    Q9VJ39 Q9VJ39

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