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    BuGZ Bub3 interacting GLEBS and Zinc finger domain protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35004, updated on 9-Dec-2024

    Summary

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    Official Symbol
    BuGZprovided by FlyBase
    Official Full Name
    Bub3 interacting GLEBS and Zinc finger domain proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032600
    Locus tag
    Dmel_CG17912
    See related
    AllianceGenome:FB:FBgn0032600
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LD27810; buGZ; CG17912; Dmel\CG17912; Dm_2L:87597; lincRNA.S1359
    Summary
    Predicted to enable DNA binding activity. Involved in dendrite morphogenesis. Located in nucleus. Is expressed in organism. Orthologous to human ZNF207 (zinc finger protein 207). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See BuGZ in Genome Data Viewer
    Location:
    36A14-36A14; 2-52 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16743405..16753704)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16743405..16753704)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene NUBP iron-sulfur cluster assembly factor 1 Neighboring gene gluon Neighboring gene Chitin and LDLR binding deacetylase 3 Neighboring gene Like Sm 7 Neighboring gene yellow-b Neighboring gene pickpocket 17 Neighboring gene Myosin heavy chain

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Splicing function of mitotic regulators links R-loop-mediated DNA damage to tumor cell killing. Wan Y, et al. J Cell Biol, 2015 Apr 27. PMID 25918225, Free PMC Article
    2. Predictive regulatory models in Drosophila melanogaster by integrative inference of transcriptional networks. Marbach D, et al. Genome Res, 2012 Jul. PMID 22456606, Free PMC Article
    3. Phase separation of BuGZ regulates gut regeneration and aging through interaction with m(6)A regulators. Zhang Q, et al. Nat Commun, 2023 Oct 23. PMID 37872148, Free PMC Article
    4. Drosophila pVALIUM10 TRiP RNAi lines cause undesired silencing of Gateway-based transgenes. Stanković D, et al. Life Sci Alliance, 2023 Feb. PMID 36446522, Free PMC Article
    5. Phase Separation in Asymmetric Cell Division. Wen W. Biochemistry, 2020 Jan 14. PMID 31617345

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phase separation of BuGZ regulates gut regeneration and aging through interaction with m[6]A regulators.
      Title: Phase separation of BuGZ regulates gut regeneration and aging through interaction with m(6)A regulators.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Bub3 interacting GLEBS and zinc finger domain protein
    Names
    BuGZ-PA
    BuGZ-PB
    BuGZ-PC
    BuGZ-PD
    BuGZ-PE
    BuGZ-PF
    BuGZ-PG
    CG17912-PA
    CG17912-PB
    CG17912-PC
    CG17912-PD
    CG17912-PE
    CG17912-PF
    CG17912-PG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      16743405..16753704
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273584.2 → NP_001260513.1  Bub3 interacting GLEBS and zinc finger domain protein, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260513.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PBC6
      Conserved Domains (2) summary
      TIGR01628
      Location:479 → 607
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      sd00017
      Location:13 → 32
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001259118.3 → NP_001246047.1  Bub3 interacting GLEBS and zinc finger domain protein, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246047.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DZ09
      Conserved Domains (2) summary
      PRK14965
      Location:201 → 251
      PRK14965; DNA polymerase III subunits gamma and tau; Provisional
      sd00017
      Location:13 → 32
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_001273583.2 → NP_001260512.1  Bub3 interacting GLEBS and zinc finger domain protein, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260512.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PG25
      Conserved Domains (1) summary
      PRK14965
      Location:199 → 249
      PRK14965; DNA polymerase III subunits gamma and tau; Provisional

    4. NM_001259117.3 → NP_001246046.1  Bub3 interacting GLEBS and zinc finger domain protein, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246046.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DZ09
      Conserved Domains (2) summary
      PRK14965
      Location:201 → 251
      PRK14965; DNA polymerase III subunits gamma and tau; Provisional
      sd00017
      Location:13 → 32
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. NM_001103697.3 → NP_001097167.1  Bub3 interacting GLEBS and zinc finger domain protein, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097167.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DZ09
      Conserved Domains (2) summary
      PRK14965
      Location:201 → 251
      PRK14965; DNA polymerase III subunits gamma and tau; Provisional
      sd00017
      Location:13 → 32
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. NM_001299057.1 → NP_001285986.1  Bub3 interacting GLEBS and zinc finger domain protein, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285986.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JED0
      Conserved Domains (2) summary
      PRK14965
      Location:201 → 251
      PRK14965; DNA polymerase III subunits gamma and tau; Provisional
      sd00017
      Location:13 → 32
      ZF_C2H2; C2H2 Zn finger [structural motif]

    7. NM_135964.3 → NP_609808.1  Bub3 interacting GLEBS and zinc finger domain protein, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609808.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q961L0, Q9VJI6
      Related
      FBpp0080450
      Conserved Domains (2) summary
      PRK14965
      Location:201 → 251
      PRK14965; DNA polymerase III subunits gamma and tau; Provisional
      sd00017
      Location:13 → 32
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8DZ09 A8DZ09
    M9PBC6 M9PBC6
    M9PG25 M9PG25
    Q8SX73 Q8SX73
    Q9VJI6 Q9VJI6
    X2JED0 X2JED0

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