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    Ufd4 Ubiquitin fusion-degradation 4-like [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34378, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ufd4provided by FlyBase
    Official Full Name
    Ubiquitin fusion-degradation 4-likeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032208
    Locus tag
    Dmel_CG5604
    See related
    AllianceGenome:FB:FBgn0032208
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5604; Dmel\CG5604; ufd4
    Summary
    Predicted to enable ubiquitin protein ligase activity. Involved in negative regulation of ERK1 and ERK2 cascade and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in nucleus. Predicted to be active in nuclear speck. Is expressed in adult head. Orthologous to human HECTD1 (HECT domain E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ufd4 in Genome Data Viewer
    Location:
    31C4-31C6; 2-40 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10281943..10292365, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10281943..10292365, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Utx histone demethylase Neighboring gene uncharacterized protein Neighboring gene hand Neighboring gene antisense RNA:CR44968 Neighboring gene Cylindromatosis

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The highly conserved cardiogenic bHLH factor Hand is specifically expressed in circular visceral muscle progenitor cells and in all cell types of the dorsal vessel during Drosophila embryogenesis. Kölsch V, et al. Dev Genes Evol, 2002 Nov. PMID 12424518
    2. RACK1 modulates polyglutamine-induced neurodegeneration by promoting ERK degradation in Drosophila. Xie J, et al. PLoS Genet, 2021 May. PMID 33983927, Free PMC Article
    3. Identification of novel genes involved in light-dependent CRY degradation through a genome-wide RNAi screen. Sathyanarayanan S, et al. Genes Dev, 2008 Jun 1. PMID 18519643, Free PMC Article
    4. The Deubiquitinase USP47 Stabilizes MAPK by Counteracting the Function of the N-end Rule ligase POE/UBR4 in Drosophila. Ashton-Beaucage D, et al. PLoS Biol, 2016 Aug. PMID 27552662, Free PMC Article
    5. Lethality in Drosophila melanogaster/Drosophila simulans species hybrids is not associated with substantial transcriptional misregulation. Barbash DA, et al. J Exp Zool B Mol Dev Evol, 2007 Jan 15. PMID 17075830

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of ERK1 and ERK2 cascade IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin fusion-degradation 4-like
    Names
    CG5604-PA
    Ufd4-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10281943..10292365 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135525.2 → NP_609369.1  ubiquitin fusion-degradation 4-like [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609369.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6NR00, Q9VL06
      Related
      FBpp0079663
      Conserved Domains (6) summary
      cd00078
      Location:2265 → 2725
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00204
      Location:396 → 509
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:393 → 420
      ANK; ANK repeat [structural motif]
      pfam06701
      Location:1333 → 1389
      MIB_HERC2; Mib_herc2
      cl23730
      Location:1173 → 1298
      F5_F8_type_C; F5/8 type C domain
      cl25750
      Location:1576 → 1725
      DamX; Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell cycle control, cell division, chromosome partitioning]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VL06.1 Q9VL06

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