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    Ggamma30A G protein gamma subunit 30A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 45234, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ggamma30Aprovided by FlyBase
    Official Full Name
    G protein gamma subunit 30Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0267252
    Locus tag
    Dmel_CG3694
    See related
    AllianceGenome:FB:FBgn0267252
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG18511; CG3694; CG43733; Dmel\CG3694; G-gamma30A; Galpha30A; Ggamma; Ggammae; Ggamma[[e]]; GNG gene like; G[[gamma30A]]; G[[gamma]]; lincRNA.S701
    Old locus tag
    Dmel_CG43733
    Summary
    Enables protein heterodimerization activity. Involved in G protein-coupled receptor signaling pathway; cellular response to carbon dioxide; and phototransduction. Located in cytoplasm and rhabdomere. Part of heterotrimeric G-protein complex. Is expressed in eye; organism subdivision; photoreceptor neurons; and synaptic neuropil domain. Orthologous to human GNG13 (G protein subunit gamma 13). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Ggamma30A in Genome Data Viewer
    Location:
    30A7-30A8; 2-35 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (9256563..9302494)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (9256563..9302494)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene lectin-30A Neighboring gene long non-coding RNA:CR45262 Neighboring gene borealin-related Neighboring gene long non-coding RNA:CR42844 Neighboring gene long non-coding RNA:CR45456

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Targeted mutagenesis of the farnesylation site of Drosophila Ggammae disrupts membrane association of the G protein betagamma complex and affects the light sensitivity of the visual system. Schillo S, et al. J Biol Chem, 2004 Aug 27. PMID 15205461
    2. G-protein gamma subunit 1 is required for sugar reception in Drosophila. Ishimoto H, et al. EMBO J, 2005 Sep 21. PMID 16121192, Free PMC Article
    3. G beta association and effector interaction selectivities of the divergent G gamma subunit G gamma(13). Blake BL, et al. J Biol Chem, 2001 Dec 28. PMID 11675383
    4. Dendrobium nobile Polysaccharide Attenuates Blue Light-Induced Injury in Retinal Cells and In Vivo in Drosophila. Hsu WH, et al. Antioxidants (Basel), 2024 May 14. PMID 38790708, Free PMC Article
    5. A novel Ggamma isolated from Drosophila constitutes a visual G protein gamma subunit of the fly compound eye. Schulz S, et al. J Biol Chem, 1999 Dec 31. PMID 10608815

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ggammae has a role in light sensitivity of the visual system
      Title: Targeted mutagenesis of the farnesylation site of Drosophila Ggammae disrupts membrane association of the G protein betagamma complex and affects the light sensitivity of the visual system.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables G-protein beta-subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G-protein beta-subunit binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to carbon dioxide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phototransduction IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in sensory perception of taste IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of heterotrimeric G-protein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of heterotrimeric G-protein complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in rhabdomere IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    G protein gamma subunit 30A
    Names
    CG3694-PA
    CG3694-PB
    CG3694-PC
    CG3694-PF
    CG3694-PG
    CG3694-PH
    CG3694-PI
    CG3694-PJ
    G protein gamma30A
    G protein subunit gamma at 30A
    Ggamma30A-PA
    Ggamma30A-PB
    Ggamma30A-PC
    Ggamma30A-PF
    Ggamma30A-PG
    Ggamma30A-PH
    Ggamma30A-PI
    Ggamma30A-PJ

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      9256563..9302494
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164852.3 → NP_723452.1  G protein gamma subunit 30A, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723452.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0H1, Q95RZ3, Q9NFZ3, Q9VLD3
      UniProtKB/TrEMBL
      E1JHC3
      Related
      FBpp0079397
      Conserved Domains (1) summary
      cd00068
      Location:11 → 67
      GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors

    2. NM_001169447.2 → NP_001162918.1  G protein gamma subunit 30A, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162918.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0H1, Q95RZ3, Q9NFZ3, Q9VLD3
      UniProtKB/TrEMBL
      E1JHC3
      Conserved Domains (1) summary
      cd00068
      Location:11 → 67
      GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors

    3. NM_001298847.1 → NP_001285776.1  G protein gamma subunit 30A, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285776.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JDM7
      Conserved Domains (1) summary
      cd00068
      Location:11 → 67
      GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors

    4. NM_080068.4 → NP_524807.1  G protein gamma subunit 30A, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524807.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0H1, Q95RZ3, Q9NFZ3, Q9VLD3
      UniProtKB/TrEMBL
      E1JHC3
      Related
      FBpp0079395
      Conserved Domains (1) summary
      cd00068
      Location:11 → 67
      GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors

    5. NM_001201820.2 → NP_001188749.1  G protein gamma subunit 30A, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188749.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0H1, Q95RZ3, Q9NFZ3, Q9VLD3
      UniProtKB/TrEMBL
      E1JHC3
      Conserved Domains (1) summary
      cd00068
      Location:11 → 67
      GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors

    6. NM_164851.3 → NP_723451.1  G protein gamma subunit 30A, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723451.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0H1, Q95RZ3, Q9NFZ3, Q9VLD3
      UniProtKB/TrEMBL
      E1JHC3
      Related
      FBpp0079396
      Conserved Domains (1) summary
      cd00068
      Location:11 → 67
      GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors

    7. NM_001259021.2 → NP_001245950.1  G protein gamma subunit 30A, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245950.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0H1, Q95RZ3, Q9NFZ3, Q9VLD3
      UniProtKB/TrEMBL
      E1JHC3
      Conserved Domains (1) summary
      cd00068
      Location:11 → 67
      GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors

    8. NM_001169446.3 → NP_001162917.2  G protein gamma subunit 30A, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162917.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JHC4
      Conserved Domains (1) summary
      cd00068
      Location:3 → 59
      GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JHC3 E1JHC3
    E1JHC4 E1JHC4
    Q9NFZ3.1 Q9NFZ3
    X2JDM7 X2JDM7

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