gammaTub23C gamma-Tubulin at 23C [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: gammaTub23Cprovided by FlyBase
Official Full Name: gamma-Tubulin at 23Cprovided by FlyBase
Primary source: FLYBASE:FBgn0260639
Locus tag: Dmel_CG3157
See related: AllianceGenome:FB:FBgn0260639
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG 3157; CG3157; D.m.GAMMA-23C; Dmel\CG3157; g-Tubulin; gamma tubulin; gamma-tub; gamma-Tub; gamma-tub 23C; gamma-tub23; gamma-tub23C; gamma-Tub23C; gamma-tubulin; GAMMA23C; gammatub; gammaTub; gammaTUB; gammatub23C; gammaTub23c; gammaTUB23C; gammaTub23CD; gammatubulin; gamma[zy]; GTU88*; gTub; GTUB; gTub23C; l(2)23Ce; Tub23; Tub23C; Tub3A; tubulin
Summary: Enables GTP binding activity. Contributes to microtubule minus-end binding activity. Involved in microtubule cytoskeleton organization; mitotic sister chromatid separation; and regulation of cell cycle. Located in cytoplasm and microtubule cytoskeleton. Part of gamma-tubulin ring complex and gamma-tubulin small complex. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 4; inclusion body myositis; and muscular disease. Orthologous to human TUBG1 (tubulin gamma 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 23C4-23C4; 2-8 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (2972891..2974858)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (2972891..2974858)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that interphase centrioles are closely associated with Sas-4, Spd-2, Polo kinase, Pericentrin-like protein (Dplp), Asterless (Asl), Plk4 kinase, Centrosomin (Cnn) and gamma-tubulin.
Title: Structured illumination of the interface between centriole and peri-centriolar material.
The genetic interactions between gammaTub23C and chromatin-remodeling mutations suggest that gamma-tubulin might have a role in regulating gene expression.
Title: gammaTub23C interacts genetically with brahma chromatin-remodeling complexes in Drosophila melanogaster.
This indicates a role for Dgrip84 in regulating the activity and/or the location of the gamma-tubulin complexes formed with gammaTub37CD and gammaTub23C.
Title: Distinct Dgrip84 isoforms correlate with distinct gamma-tubulins in Drosophila.
findings showed that the molecular requirements for a functional spindle checkpoint included components of the large gamma-tubulin ring complex; however, their localization at the centrosome and centrosome integrity were not essential for this function
Title: A centrosome-independent role for gamma-TuRC proteins in the spindle assembly checkpoint.
gamma-tubulin is required for female germ-cell proliferation and that the two gamma-tubulins present in Drosophila are functionally equivalent during female germ-cell development and oogenesis.
Title: gamma-Tubulin function during female germ-cell development and oogenesis in Drosophila.
extensively recruited to the centrosome during mitosis and relocalizes in the mitotic spindle.
Title: Differential properties of the two Drosophila gamma-tubulin isotypes.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables guanyl nucleotide binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to microtubule minus-end binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule nucleator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in centriole-centriole cohesion	IDA Inferred from Direct Assay more info	PubMed
involved_in centrosome cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytoplasmic microtubule organization	IEA Inferred from Electronic Annotation more info
involved_in meiotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule nucleation	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule nucleation	IDA Inferred from Direct Assay more info	PubMed
involved_in microtubule nucleation	IEA Inferred from Electronic Annotation more info
involved_in microtubule nucleation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cell cycle	HMP more info	PubMed
involved_in mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic sister chromatid segregation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic sister chromatid separation	IDA Inferred from Direct Assay more info	PubMed
involved_in mitotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
part_of gamma-tubulin complex	IEA Inferred from Electronic Annotation more info
part_of gamma-tubulin complex	IPI Inferred from Physical Interaction more info	PubMed
part_of gamma-tubulin ring complex	IBA Inferred from Biological aspect of Ancestor more info
part_of gamma-tubulin ring complex	IDA Inferred from Direct Assay more info	PubMed
part_of gamma-tubulin small complex	IPI Inferred from Physical Interaction more info	PubMed
located_in microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in pericentriolar material	IDA Inferred from Direct Assay more info	PubMed
is_active_in spindle	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: gamma-Tubulin at 23C

Names: 23C gamma-tubulin; 23C-gamma-tubulin; CG3157-PA; gama-tubulin; gamma tubulin; gamma tubulin 23C; gamma-Tubulin; gamma-tubulin (23C); gamma-tubulin 23C; gamma-tubulin(23C); gamma-tubulin-1; gamma-tubulin23C; gammaTub23C-PA; gammatubulin; lethal (2) 23Ce; tubulin

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

2972891..2974858

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057456.4 → NP_476804.1 gamma-Tubulin at 23C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476804.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P23257, Q9VQJ5

Related

FBpp0077326

Conserved Domains (2) summary

PLN00222
Location:1 → 451

PLN00222; tubulin gamma chain; Provisional

cd02188
Location:4 → 440

gamma_tubulin; The gamma-tubulin family