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    Rrp1 Recombination repair protein 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33500, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rrp1provided by FlyBase
    Official Full Name
    Recombination repair protein 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0004584
    Locus tag
    Dmel_CG3178
    See related
    AllianceGenome:FB:FBgn0004584
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    3178; APEX1; CG3178; Dmel\CG3178; rrp; Rrp-1; RRP1; RRP1_DROME
    Summary
    Enables 3'-5' exonuclease activity; DNA polymerase binding activity; and class II DNA-(apurinic or apyrimidinic site) endonuclease activity. Predicted to be involved in base-excision repair. Predicted to be active in nucleus. Is expressed in several structures, including CNS glial cell; embryonic/larval midgut primordium; ganglia; head epidermis primordium; and mesoderm. Human ortholog(s) of this gene implicated in artery disease (multiple); breast cancer; female reproductive organ cancer (multiple); spina bifida; and urinary bladder cancer. Orthologous to human APEX1 (apurinic/apyrimidinic endodeoxyribonuclease 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rrp1 in Genome Data Viewer
    Location:
    23C3-23C4; 2-8 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2969773..2972508, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2969773..2972508, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene lilliputian Neighboring gene RNA-binding protein 9 Neighboring gene gamma-Tubulin at 23C Neighboring gene Thymidylate synthase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of Rrp1, the gene encoding Drosophila strand transferase: carboxy-terminal homology to DNA repair endo/exonucleases. Sander M, et al. Nucleic Acids Res, 1991 Aug 25. PMID 1653418, Free PMC Article
    2. Drosophila Rrp1 domain structure as defined by limited proteolysis and biophysical analyses. Reardon BJ, et al. J Biol Chem, 1998 Dec 18. PMID 9852053
    3. Drosophila Rrp1 protein: an apurinic endonuclease with homologous recombination activities. Sander M, et al. Proc Natl Acad Sci U S A, 1991 Aug 1. PMID 1713691, Free PMC Article
    4. Drosophila Rrp1 3'-exonuclease: demonstration of DNA sequence dependence and DNA strand specificity. Sander M, et al. Nucleic Acids Res, 1996 Oct 15. PMID 8918793, Free PMC Article
    5. Drosophila melanogaster strand transferase. A protein that forms heteroduplex DNA in the absence of both ATP and single-strand DNA binding protein. Lowenhaupt K, et al. J Biol Chem, 1989 Dec 5. PMID 2555365

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 3'-5' exonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA polymerase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables DNA-(apurinic or apyrimidinic site) endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-(apurinic or apyrimidinic site) endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables class II DNA-(apurinic or apyrimidinic site) endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables double-stranded DNA 3'-5' DNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoric diester hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in base-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    recombination repair protein 1
    Names
    CG3178-PA
    CG3178-PB
    Rrp1-PA
    Rrp1-PB
    strand transferase
    NP_001137776.1
    NP_476841.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      2969773..2972508 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057493.4 → NP_476841.1  recombination repair protein 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476841.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P27864, Q540Y1, Q9VQJ4
      Related
      FBpp0077362
      Conserved Domains (3) summary
      cd09087
      Location:427 → 677
      Ape1-like_AP-endo; Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases
      pfam06459
      Location:314 → 388
      RR_TM4-6; Ryanodine Receptor TM 4-6
      cl00936
      Location:15 → 217
      RecX; RecX family

    2. NM_001144304.2 → NP_001137776.1  recombination repair protein 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137776.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZZ9
      Conserved Domains (3) summary
      cd09087
      Location:454 → 704
      Ape1-like_AP-endo; Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases
      pfam06459
      Location:314 → 388
      RR_TM4-6; Ryanodine Receptor TM 4-6
      cl00936
      Location:15 → 217
      RecX; RecX family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7YZZ9 B7YZZ9
    P27864.2 P27864

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