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    Start1 Start1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37927, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Start1provided by FlyBase
    Official Full Name
    Start1provided by FlyBase
    Primary source
    FLYBASE:FBgn0035028
    Locus tag
    Dmel_CG3522
    See related
    AllianceGenome:FB:FBgn0035028
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3522; Dmel\CG3522; Start; start1; StART1
    Summary
    Predicted to enable cholesterol binding activity. Predicted to be involved in cholesterol transport and vesicle tethering to endoplasmic reticulum. Predicted to be active in endoplasmic reticulum-endosome membrane contact site and late endosome membrane. Predicted to colocalize with endoplasmic reticulum membrane. Is expressed in several structures, including dorsal ectoderm; dorsal epidermis primordium; gland; gonad; and nurse cell. Orthologous to several human genes including STARD3 (StAR related lipid transfer domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Start1 in Genome Data Viewer
    Location:
    60D5-60D5; 2-107 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24574559..24577676)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20462082..20465199)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene unconventional prefoldin RPB5 interactor Neighboring gene TFIIF-interacting CTD phosphatase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene SIFamide Neighboring gene piopio

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila gene Start1: a putative cholesterol transporter and key regulator of ecdysteroid synthesis. Roth GE, et al. Proc Natl Acad Sci U S A, 2004 Feb 10. PMID 14745013, Free PMC Article
    2. Case studies of ends-out gene targeting in Drosophila. Chen H, et al. Genesis, 2009 May. PMID 19298016
    3. The Fruit Fly Drosophila melanogaster as a Model System to Study Cholesterol Metabolism and Homeostasis. Niwa R, et al. Cholesterol, 2011. PMID 21512589, Free PMC Article
    4. New players in the regulation of ecdysone biosynthesis. Huang X, et al. J Genet Genomics, 2008 Jan. PMID 18222403
    5. br regulates the expression of the ecdysone biosynthesis gene npc1. Xiang Y, et al. Dev Biol, 2010 Aug 15. PMID 20621708

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. plays a key role in the regulation of ecdysteroid synthesis
      Title: The Drosophila gene Start1: a putative cholesterol transporter and key regulator of ecdysteroid synthesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cholesterol binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cholesterol transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in vesicle tethering to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    colocalizes_with endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum-endosome membrane contact site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in late endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in late endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Start1
    Names
    CG3522-PA
    CG3522-PB
    CG3522-PC
    CG3522-PD
    Start1-PA
    Start1-PB
    Start1-PC
    Start1-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24574559..24577676
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206217.3 → NP_995939.1  Start1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995939.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W145
      Conserved Domains (2) summary
      pfam10457
      Location:57 → 232
      MENTAL; Cholesterol-capturing domain
      cl14643
      Location:247 → 360
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

    2. NM_001259566.2 → NP_001246495.1  Start1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246495.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MZH4, Q9W145
      Conserved Domains (2) summary
      pfam10457
      Location:57 → 232
      MENTAL; Cholesterol-capturing domain
      cl14643
      Location:247 → 571
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

    3. NM_138092.3 → NP_611936.2  Start1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611936.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MZH4, Q9W145
      Related
      FBpp0088807
      Conserved Domains (2) summary
      pfam10457
      Location:57 → 232
      MENTAL; Cholesterol-capturing domain
      cl14643
      Location:247 → 571
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

    4. NM_001299919.1 → NP_001286848.1  Start1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286848.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LGM4
      Conserved Domains (1) summary
      cl14643
      Location:3 → 331
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LGM4 A0A0B4LGM4
    Q9W145.2 Q9W145

    Gene LinkOut

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