Sesn Sestrin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Sesnprovided by FlyBase
Official Full Name: Sestrinprovided by FlyBase
Primary source: FLYBASE:FBgn0034897
Locus tag: Dmel_CG11299
See related: AllianceGenome:FB:FBgn0034897
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:GH20113; BEST:GH20113; CG11299; Dmel\CG11299; dSesn; sesn
Summary: Enables amino acid sensor activity. Involved in several processes, including cellular response to L-leucine; cellular response to leucine starvation; and negative regulation of TORC1 signaling. Acts upstream of with a positive effect on regulation of foraging behavior. Predicted to be located in nucleus. Is expressed in organism. Orthologous to several human genes including SESN2 (sestrin 2) and SESN3 (sestrin 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (23713900..23734846)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (19601423..19622369)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables L-leucine binding	IBA Inferred from Biological aspect of Ancestor more info
enables amino acid sensor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables oxidoreductase activity, acting on peroxide as acceptor	IBA Inferred from Biological aspect of Ancestor more info
enables peroxidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to L-leucine	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to L-leucine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to leucine starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to leucine starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of TORC1 signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of macroautophagy	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_positive_effect regulation of foraging behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of response to reactive oxygen species	IEA Inferred from Electronic Annotation more info