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    twz tiwaz [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37456, updated on 27-Dec-2024

    Summary

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    Official Symbol
    twzprovided by FlyBase
    Official Full Name
    tiwazprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034636
    Locus tag
    Dmel_CG10440
    See related
    AllianceGenome:FB:FBgn0034636
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10440; Dmel\CG10440; Twz
    Summary
    Predicted to enable transcription corepressor activity. Involved in several processes, including adult feeding behavior; inter-male aggressive behavior; and positive regulation of octopamine signaling pathway. Is expressed in several structures, including CNS glial cell; central brain primordium; embryonic central brain neurons; embryonic head epidermis; and ganglia. Human ortholog(s) of this gene implicated in scalp-ear-nipple syndrome. Orthologous to human KCTD1 (potassium channel tetramerization domain containing 1) and KCTD15 (potassium channel tetramerization domain containing 15). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See twz in Genome Data Viewer
    Location:
    57F1-57F2; 2-96 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21560246..21576035, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17447751..17463540, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Epidermal growth factor receptor Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of aggression by obesity-linked genes TfAP-2 and Twz through octopamine signaling in Drosophila. Williams MJ, et al. Genetics, 2014 Jan. PMID 24142897, Free PMC Article
    2. A single-cell transcriptomic atlas of the adult Drosophila ventral nerve cord. Allen AM, et al. Elife, 2020 Apr 21. PMID 32314735, Free PMC Article
    3. Obesity-linked homologues TfAP-2 and Twz establish meal frequency in Drosophila melanogaster. Williams MJ, et al. PLoS Genet, 2014 Sep. PMID 25187989, Free PMC Article
    4. Comparison of dot chromosome sequences from D. melanogaster and D. virilis reveals an enrichment of DNA transposon sequences in heterochromatic domains. Slawson EE, et al. Genome Biol, 2006. PMID 16507169, Free PMC Article
    5. Cholecystokinin-Like Peptide (DSK) in Drosophila, Not Only for Satiety Signaling. Nässel DR, et al. Front Endocrinol (Lausanne), 2014. PMID 25566191, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in adult feeding behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in inter-male aggressive behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male courtship behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of octopamine signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tiwaz
    Names
    CG10440-PA
    CG10440-PB
    twz-PA
    twz-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      21560246..21576035 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259520.1 → NP_001246449.1  tiwaz, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246449.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D5SHR0, Q9W2F9
      Conserved Domains (1) summary
      cd18361
      Location:137 → 230
      BTB_POZ_KCTD1-like; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD1 and KCTD15

    2. NM_137744.2 → NP_611588.1  tiwaz, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611588.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W2F9
      Related
      FBpp0071609
      Conserved Domains (1) summary
      cd18361
      Location:108 → 201
      BTB_POZ_KCTD1-like; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD1 and KCTD15
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D5SHR0.1 D5SHR0

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