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    ena enabled [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37201, updated on 9-Dec-2024

    Summary

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    Official Symbol
    enaprovided by FlyBase
    Official Full Name
    enabledprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000578
    Locus tag
    Dmel_CG15112
    See related
    AllianceGenome:FB:FBgn0000578
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15112; Dmel\CG15112; Ena; ENA/VASP; Enabled; enb; Enb; l(2)02029; Vasp; VASP
    Summary
    Enables SH3 domain binding activity. Involved in several processes, including embryonic development via the syncytial blastoderm; plasma membrane bounded cell projection organization; and regulation of plasma membrane bounded cell projection assembly. Located in several cellular components, including filopodium tip; lamellipodium; and subsynaptic reticulum. Colocalizes with adherens junction. Is expressed in several structures, including epithelial cell; epithelium; ganglia; neuron projection bundle of larval ventral nerve cord; and visceral mesoderm derivative. Orthologous to several human genes including ENAH (ENAH actin regulator). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ena in Genome Data Viewer
    Location:
    56B5-56C1; 2-88 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (19141632..19163705)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (15029137..15051210)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43399 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene happyhour

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Enabled primarily controls filopodial morphology, not actin organization, in the TSM1 growth cone in Drosophila. Fang HY, et al. Mol Biol Cell, 2023 Jul 1. PMID 37223966, Free PMC Article
    2. Relaxing the actin cytoskeleton for adhesion and movement with Ena/VASP. Trichet L, et al. J Cell Biol, 2008 Apr 7. PMID 18378777, Free PMC Article
    3. Ena/VASP Enabled is a highly processive actin polymerase tailored to self-assemble parallel-bundled F-actin networks with Fascin. Winkelman JD, et al. Proc Natl Acad Sci U S A, 2014 Mar 18. PMID 24591594, Free PMC Article
    4. The actin regulators Enabled and Diaphanous direct distinct protrusive behaviors in different tissues during Drosophila development. Nowotarski SH, et al. Mol Biol Cell, 2014 Oct 15. PMID 25143400, Free PMC Article
    5. Enabled negatively regulates diaphanous-driven actin dynamics in vitro and in vivo. Bilancia CG, et al. Dev Cell, 2014 Feb 24. PMID 24576424, Free PMC Article

    See all (324) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Enabled primarily controls filopodial morphology, not actin organization, in the TSM1 growth cone in Drosophila.
      Title: Enabled primarily controls filopodial morphology, not actin organization, in the TSM1 growth cone in Drosophila.
    2. Enabled/VASP is required to mediate proper sealing of opposing cardioblasts during Drosophila dorsal vessel formation.
      Title: Enabled/VASP is required to mediate proper sealing of opposing cardioblasts during Drosophila dorsal vessel formation.
    3. Drosophila enabled promotes synapse morphogenesis and regulates active zone form and function.
      Title: Drosophila enabled promotes synapse morphogenesis and regulates active zone form and function.
    4. Drosophila Atg9 regulates the actin cytoskeleton via interactions with profilin and Ena.
      Title: Drosophila Atg9 regulates the actin cytoskeleton via interactions with profilin and Ena.
    5. Developmental axon regrowth and primary neuron sprouting utilize distinct actin elongation factors.
      Title: Developmental axon regrowth and primary neuron sprouting utilize distinct actin elongation factors.
    6. this study shows that Ena orchestrates remodelling within the actin cytoskeleton to drive robust Drosophila macrophage chemotaxis during inflammation
      Title: Ena orchestrates remodelling within the actin cytoskeleton to drive robust Drosophila macrophage chemotaxis.
    7. The Abl tyrosine kinase signaling network controls cell migration, epithelial organization, axon patterning and other aspects of development. Abl suppresses the actin-regulatory factor Enabled, and we find that Abl also acts through the GEF Trio to stimulate the signaling activity of Rac GTPase.
      Title: The Abl pathway bifurcates to balance Enabled and Rac signaling in axon patterning in Drosophila.
    8. Abl/Ena signaling controls the subcellular architecture of the Golgi complex in Drosophila photoreceptor neurons through its regulation of the Golgi-associated actin cytoskeleton.
      Title: The Abl/enabled signaling pathway regulates Golgi architecture in Drosophila photoreceptor neurons.
    9. the activities of Ena/VASP and the WAVE regulatory complex are intimately linked to ensure optimal control of actin polymerization during cell migration and development
      Title: Ena/VASP proteins cooperate with the WAVE complex to regulate the actin cytoskeleton.
    10. Ena is both sufficient and necessary to account for miR-8-mediated regulation of subsynaptic reticulum architecture.
      Title: miR-8 controls synapse structure by repression of the actin regulator enabled.
    Submit: New GeneRIF Correction See all GeneRIFs (21)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables SH3 domain binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables SH3 domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in actin filament organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in actin polymerization or depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in axon guidance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in border follicle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in compound eye development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal closure IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in epithelial cell morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in filopodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in formation of a compartment boundary IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germ-band shortening IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gonad morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in head involution IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of synaptic assembly at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ovarian nurse cell to oocyte transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell projection organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cell projection organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of filopodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of actin cytoskeleton organization IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in regulation of filopodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of lamellipodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in subsynaptic reticulum organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in suture of dorsal opening IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    colocalizes_with adherens junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell leading edge IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with cell-cell junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in filopodium tip IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in filopodium tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in subsynaptic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    enabled
    Names
    CG15112-PA
    CG15112-PB
    CG15112-PC
    CG15112-PD
    CG15112-PE
    CG15112-PF
    CG15112-PG
    VASP
    ena-PA
    ena-PB
    ena-PC
    ena-PD
    ena-PE
    ena-PF
    ena-PG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      19141632..19163705
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299673.1 → NP_001286602.1  enabled, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286602.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LFX0
      Conserved Domains (2) summary
      cd01207
      Location:5 → 112
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
      pfam08776
      Location:629 → 663
      VASP_tetra; VASP tetramerization domain

    2. NM_166330.2 → NP_725858.1  enabled, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725858.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T4F7
      Related
      FBpp0085766
      Conserved Domains (2) summary
      cd01207
      Location:5 → 112
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
      pfam08776
      Location:649 → 683
      VASP_tetra; VASP tetramerization domain

    3. NM_001014536.2 → NP_001014536.1  enabled, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014536.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T4F7
      Conserved Domains (2) summary
      cd01207
      Location:5 → 112
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
      pfam08776
      Location:649 → 683
      VASP_tetra; VASP tetramerization domain

    4. NM_166329.2 → NP_725857.1  enabled, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725857.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T4F7
      Related
      FBpp0085767
      Conserved Domains (2) summary
      cd01207
      Location:5 → 112
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
      pfam08776
      Location:649 → 683
      VASP_tetra; VASP tetramerization domain

    5. NM_001014537.3 → NP_001014537.1  enabled, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014537.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T4F7
      Conserved Domains (2) summary
      cd01207
      Location:5 → 112
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
      pfam08776
      Location:652 → 686
      VASP_tetra; VASP tetramerization domain

    6. NM_001144237.2 → NP_001137709.1  enabled, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137709.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZP3, B7YZL0, Q24035, Q86NN6, Q8MMB3, Q8T4F7, Q9V8R3
      Conserved Domains (2) summary
      cd01207
      Location:301 → 408
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
      pfam08776
      Location:945 → 979
      VASP_tetra; VASP tetramerization domain

    7. NM_166331.3 → NP_725859.2  enabled, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725859.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T4F7
      Conserved Domains (2) summary
      cd01207
      Location:150 → 257
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
      pfam08776
      Location:799 → 833
      VASP_tetra; VASP tetramerization domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LFX0 A0A0B4LFX0
    Q8T4F7.4 Q8T4F7

    Gene LinkOut

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