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    mute muscle wasted [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 2768848, updated on 9-Dec-2024

    Summary

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    Official Symbol
    muteprovided by FlyBase
    Official Full Name
    muscle wastedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0085444
    Locus tag
    Dmel_CG34415
    See related
    AllianceGenome:FB:FBgn0085444
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15610; CG33455; CG33456; CG34415; Dmel\CG34415; Mute
    Old locus tag
    CG33455; CG33456; Dmel_CG33455; Dmel_CG33456
    Summary
    Predicted to enable transcription coregulator activity. Involved in muscle cell cellular homeostasis. Located in histone locus body. Is expressed in adult heart; larval somatic muscle cell; and organism. Orthologous to several human genes including GON4L (gon-4 like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mute in Genome Data Viewer
    Location:
    53E2-53E2; 2-81 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16948296..16955266, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12835801..12842771, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Vacuolar H[+] ATPase 16kD subunit 4 Neighboring gene Ubiquitin-fold modifier 1 Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class V Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Interaction between FLASH and Lsm11 is essential for histone pre-mRNA processing in vivo in Drosophila. Burch BD, et al. RNA, 2011 Jun. PMID 21525146, Free PMC Article
    2. A sequence in the Drosophila H3-H4 Promoter triggers histone locus body assembly and biosynthesis of replication-coupled histone mRNAs. Salzler HR, et al. Dev Cell, 2013 Mar 25. PMID 23537633, Free PMC Article
    3. Organ identity specification factor WGE localizes to the histone locus body and regulates histone expression to ensure genomic stability in Drosophila. Ozawa N, et al. Genes Cells, 2016 May. PMID 27145109
    4. A conserved interaction that is essential for the biogenesis of histone locus bodies. Yang XC, et al. J Biol Chem, 2014 Dec 5. PMID 25339177, Free PMC Article
    5. Drosophila histone locus body assembly and function involves multiple interactions. Koreski KP, et al. Mol Biol Cell, 2020 Jul 1. PMID 32401666, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in muscle cell cellular homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ventral cord development HMP PubMed 
    Component Evidence Code Pubs
    located_in histone locus body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in histone locus body IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    muscle wasted
    Names
    CG34415-PC
    CG34415-PD
    mute-PC
    mute-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16948296..16955266 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001103882.3 → NP_001097352.1  muscle wasted, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097352.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYH1

    2. NM_206141.2 → NP_995863.1  muscle wasted, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995863.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MS31
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8DYH1 A8DYH1
    Q8MS31 Q8MS31

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