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    CG8060 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36824, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG8060provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034113
    Locus tag
    Dmel_CG8060
    See related
    AllianceGenome:FB:FBgn0034113
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG8060
    Summary
    Predicted to enable protein tyrosine kinase inhibitor activity. Predicted to be involved in release of sequestered calcium ion into cytosol. Predicted to be located in nucleoplasm. Orthologous to human IBTK (inhibitor of Bruton tyrosine kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG8060 in Genome Data Viewer
    Location:
    53B4-53B4; 2-79 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16316313..16320732, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12203818..12208237, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45232 Neighboring gene Autophagy-related 9 Neighboring gene NADPH oxidase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mes2, a MADF-containing transcription factor essential for Drosophila development. Zimmermann G, et al. Dev Dyn, 2006 Dec. PMID 17029287
    2. Modularity and hormone sensitivity of the Drosophila melanogaster insulin receptor/target of rapamycin interaction proteome. Glatter T, et al. Mol Syst Biol, 2011 Nov 8. PMID 22068330, Free PMC Article
    3. The Septate Junction Protein Tsp2A Restricts Intestinal Stem Cell Activity via Endocytic Regulation of aPKC and Hippo Signaling. Xu C, et al. Cell Rep, 2019 Jan 15. PMID 30650359, Free PMC Article
    4. Protein phosphorylation changes reveal new candidates in the regulation of egg activation and early embryogenesis in D. melanogaster. Krauchunas AR, et al. Dev Biol, 2012 Oct 1. PMID 22884528, Free PMC Article
    5. Analysis of the expression patterns, subcellular localisations and interaction partners of Drosophila proteins using a pigP protein trap library. Lowe N, et al. Development, 2014 Oct. PMID 25294943, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein tyrosine kinase inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in release of sequestered calcium ion into cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8060-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16316313..16320732 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137273.3 → NP_611117.2  uncharacterized protein Dmel_CG8060 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611117.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZAE2, Q95R60
      Related
      FBpp0086322
      Conserved Domains (9) summary
      smart00225
      Location:697 → 798
      BTB; Broad-Complex, Tramtrack and Bric a brac
      cd00204
      Location:46 → 138
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14821
      Location:798 → 834
      SPOP_C_like; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins
      pfam00415
      Location:147 → 195
      RCC1; Regulator of chromosome condensation (RCC1) repeat
      pfam00651
      Location:684 → 795
      BTB; BTB/POZ domain
      pfam12796
      Location:95 → 138
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:57 → 111
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:56 → 87
      ANK; ANK repeat [structural motif]
      cl02518
      Location:547 → 635
      BTB; BTB/POZ domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1ZAE2 A1ZAE2
    Q95R60 Q95R60

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