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    Erasp Endoplasmic reticulum stress-associated serine protease [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 246448, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Eraspprovided by FlyBase
    Official Full Name
    Endoplasmic reticulum stress-associated serine proteaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0050090
    Locus tag
    Dmel_CG30090
    See related
    AllianceGenome:FB:FBgn0050090
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH21666; CG30090; CG8215; Dmel\CG30090; SP220; SP41
    Summary
    Enables serine-type endopeptidase activity. Involved in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Erasp in Genome Data Viewer
    Location:
    52C1-52C1; 2-75 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15689826..15691014)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11577331..11578519)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Importin beta11 Neighboring gene uncharacterized protein Neighboring gene Centrosomal protein 89kDa Neighboring gene antisense RNA:CR44372 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mycobacterium abscessus resists the innate cellular response by surviving cell lysis of infected phagocytes. Touré H, et al. PLoS Pathog, 2023 Mar. PMID 36972320, Free PMC Article
    2. Genome-Wide Analysis Reveals Novel Regulators of Growth in Drosophila melanogaster. Vonesch SC, et al. PLoS Genet, 2016 Jan. PMID 26751788, Free PMC Article
    3. Glial ferritin maintains neural stem cells via transporting iron required for self-renewal in Drosophila. Ma Z, et al. Elife, 2024 Sep 10. PMID 39255019, Free PMC Article
    4. Drosophila activating transcription factor-2 is involved in stress response via activation by p38, but not c-Jun NH(2)-terminal kinase. Sano Y, et al. Mol Biol Cell, 2005 Jun. PMID 15788564, Free PMC Article
    5. Functional genomics of the evolution of increased resistance to parasitism in Drosophila. Wertheim B, et al. Mol Ecol, 2011 Mar. PMID 21062384

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    endoplasmic reticulum stress-associated serine protease
    Names
    CG30090-PA
    ER stress-associated serine protease
    Erasp-PA
    NP_725487.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      15689826..15691014
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166112.2 → NP_725487.1  endoplasmic reticulum stress-associated serine protease [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725487.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JRM2
      Related
      FBpp0086417
      Conserved Domains (2) summary
      smart00020
      Location:39 → 273
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:40 → 276
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JRM2 Q7JRM2

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