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    Fs Follistatin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 2768836, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fsprovided by FlyBase
    Official Full Name
    Follistatinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0259878
    Locus tag
    Dmel_CG33466
    See related
    AllianceGenome:FB:FBgn0259878
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12955; CG12956; CG33466; dFol1; dfs; dFS; Dmel\CG33466; Fol1; fs
    Summary
    Enables activin binding activity. Involved in negative regulation of BMP signaling pathway; negative regulation of activin receptor signaling pathway; and positive regulation of activin receptor signaling pathway. Located in extracellular region. Is expressed in several structures, including brain; germline cell; gonad; imaginal disc; and photoreceptor. Human ortholog(s) of this gene implicated in polycystic ovary syndrome. Orthologous to several human genes including FST (follistatin). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    51E7-51E10; 2-74 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15223560..15241589, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11111065..11129094, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44463 Neighboring gene antisense RNA:CR44370 Neighboring gene uncharacterized protein Neighboring gene Hexokinase C Neighboring gene scab Neighboring gene Integrin alphaPS4 subunit Neighboring gene Transient receptor potential cation channel, subfamily M

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation of Drosophila activin and follistatin cDNAs using novel MACH amplification protocols. Haerry TE, et al. Gene, 2002 May 29. PMID 12095682
    2. Drosophila activins adapt gut size to food intake and promote regenerative growth. Christensen CF, et al. Nat Commun, 2024 Jan 4. PMID 38177201, Free PMC Article
    3. Proliferative stem cells maintain quiescence of their niche by secreting the Activin inhibitor Follistatin. Herrera SC, et al. Dev Cell, 2021 Aug 23. PMID 34363758, Free PMC Article
    4. Drosophila Follistatin exhibits unique structural modifications and interacts with several TGF-beta family members. Bickel D, et al. Mech Dev, 2008 Jan-Feb. PMID 18077144, Free PMC Article
    5. Follistatin preferentially antagonizes activin rather than BMP signaling in Drosophila. Pentek J, et al. Genesis, 2009 Apr. PMID 19241394

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Proliferative stem cells maintain quiescence of their niche by secreting the Activin inhibitor Follistatin.
      Title: Proliferative stem cells maintain quiescence of their niche by secreting the Activin inhibitor Follistatin.
    2. FS proteins may also function in facilitating ligand diffusion. We find that mutants of daw are rescued in significant numbers by expression of vertebrate follistatin (FS) proteins
      Title: Drosophila Follistatin exhibits unique structural modifications and interacts with several TGF-beta family members.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables activin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of BMP signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of activin receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of activin receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    follistatin
    Names
    CG33466-PA
    CG33466-PB
    Fs-PA
    Fs-PB
    dFollistatin
    follistatin 1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      15223560..15241589 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299516.1 → NP_001286445.1  follistatin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286445.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LFH4, Q8WR59
      Conserved Domains (2) summary
      smart00280
      Location:563 → 603
      KAZAL; Kazal type serine protease inhibitors
      cd00104
      Location:653 → 686
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

    2. NM_144119.3 → NP_652376.2  follistatin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652376.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86NV3, Q8WR59
      Conserved Domains (2) summary
      smart00280
      Location:564 → 604
      KAZAL; Kazal type serine protease inhibitors
      cd00104
      Location:654 → 687
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LFH4 A0A0B4LFH4
    Q86NV3 Q86NV3
    Q8WR59 Q8WR59

    Gene LinkOut

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