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    CG8093 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36686, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG8093provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033999
    Locus tag
    Dmel_CG8093
    See related
    AllianceGenome:FB:FBgn0033999
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CT22063; Dmel\CG8093
    Summary
    Enables lipase activity. Involved in glucose homeostasis and response to lipid. Is active in extracellular space. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 8. Orthologous to human LIPK (lipase family member K); LIPM (lipase family member M); and LIPN (lipase family member N). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG8093 in Genome Data Viewer
    Location:
    51E7-51E7; 2-74 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15214060..15215686, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11101565..11103191, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Ionotropic receptor 51a Neighboring gene relative of woc Neighboring gene Ionotropic receptor 51b Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44463 Neighboring gene mitochondrial ribosomal protein L41

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ceramide Synthase Schlank Is a Transcriptional Regulator Adapting Gene Expression to Energy Requirements. Sociale M, et al. Cell Rep, 2018 Jan 23. PMID 29386138
    2. A nutrient responsive lipase mediates gut-brain communication to regulate insulin secretion in Drosophila. Singh A, et al. Nat Commun, 2024 May 23. PMID 38782979, Free PMC Article
    3. Altered lipid homeostasis in Drosophila InsP3 receptor mutants leads to obesity and hyperphagia. Subramanian M, et al. Dis Model Mech, 2013 May. PMID 23471909, Free PMC Article
    4. Survival response to increased ceramide involves metabolic adaptation through novel regulators of glycolysis and lipolysis. Nirala NK, et al. PLoS Genet, 2013 Jun. PMID 23818862, Free PMC Article
    5. Dietary Supplementation with Milk Lipids Leads to Suppression of Developmental and Behavioral Phenotypes of Hyperexcitable Drosophila Mutants. Kasuya J, et al. Neuroscience, 2023 Jun 1. PMID 37004908, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables hydrolase activity, acting on ester bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables triacylglycerol lipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to lipid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in sexual reproduction HEP PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8093-PA
    CG8093-PB
    triglyceride lipase
    NP_001286441.1
    NP_611020.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      15214060..15215686 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299512.1 → NP_001286441.1  uncharacterized protein Dmel_CG8093, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286441.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V6L4
      Conserved Domains (3) summary
      PLN02872
      Location:9 → 392
      PLN02872; triacylglycerol lipase
      pfam04083
      Location:31 → 92
      Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
      pfam12695
      Location:74 → 214
      Abhydrolase_5; Alpha/beta hydrolase family

    2. NM_137176.2 → NP_611020.1  uncharacterized protein Dmel_CG8093, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611020.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V6L4
      Related
      FBpp0086532
      Conserved Domains (3) summary
      PLN02872
      Location:9 → 392
      PLN02872; triacylglycerol lipase
      pfam04083
      Location:31 → 92
      Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
      pfam12695
      Location:74 → 214
      Abhydrolase_5; Alpha/beta hydrolase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4V6L4 Q4V6L4

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