Rpn6 Regulatory particle non-ATPase 6 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Rpn6provided by FlyBase
Official Full Name: Regulatory particle non-ATPase 6provided by FlyBase
Primary source: FLYBASE:FBgn0028689
Locus tag: Dmel_CG10149
See related: AllianceGenome:FB:FBgn0028689
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA.LD18931; BcDNA:LD18931; CG10149; CG5289; Dmel\CG10149; dPSMD11; l(2)k00103; p42B; Pros44.5; rpn6; RPN6; S9
Summary: Predicted to enable structural molecule activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Part of proteasome regulatory particle. Is expressed in adult head; gamma Kenyon cell; and organism. Orthologous to human PSMD11 (proteasome 26S subunit, non-ATPase 11). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (14750166..14752910, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (10637671..10640415, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

PSMD11 loss-of-function variants correlate with a neurobehavioral phenotype, obesity, and increased interferon response.
Title: PSMD11 loss-of-function variants correlate with a neurobehavioral phenotype, obesity, and increased interferon response.
Rpn6 has a pivotal role in stabilizing the otherwise weak interaction between the core particle and the regulatory particle.
Title: The proteasomal subunit Rpn6 is a molecular clamp holding the core and regulatory subcomplexes together.
Analyses of an Rpn6 P element insertion mutant and newly generated Rpn6 alleles reveal that Rpn6 is essential for Drosophila development.
Title: The proteasome regulatory particle subunit Rpn6 is required for Drosophila development and interacts physically with signalosome subunit Alien/CSN2.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural molecule activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IC Inferred by Curator more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of proteasome complex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome regulatory particle	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome regulatory particle	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of proteasome regulatory particle, lid subcomplex	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome regulatory particle, lid subcomplex	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Names: CG10149-PA; CG10149-PB; CG10149-PC; Rpn6-PA; Rpn6-PB; Rpn6-PC; proteasome p44.5 subunit

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