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    GLaz Glial Lazarillo [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36447, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GLazprovided by FlyBase
    Official Full Name
    Glial Lazarilloprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033799
    Locus tag
    Dmel_CG4604
    See related
    AllianceGenome:FB:FBgn0033799
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4604; dGLaz; DGLaz; Dmel\CG4604; glaz; Glaz
    Summary
    Enables lipoprotein particle receptor binding activity. Involved in several processes, including cellular response to oxidative stress; determination of adult lifespan; and lipid homeostasis. Located in extracellular space. Is expressed in several structures, including amnioserosa; anal pad primordium; clypeo-labral primordium; embryonic hindgut; and glial cell. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See GLaz in Genome Data Viewer
    Location:
    49F4-49F4; 2-68 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13163959..13168032, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9051464..9055537, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Tripeptidyl-peptidase II Neighboring gene NADH dehydrogenase (ubiquinone) MWFE subunit Neighboring gene Neurospecific receptor kinase Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45142 Neighboring gene Serine palmitoyltransferase subunit I Neighboring gene 1,4-Alpha-Glucan Branching Enzyme

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An automated image analysis method to measure regularity in biological patterns: a case study in a Drosophila neurodegenerative model. Diez-Hermano S, et al. Mol Neurodegener, 2015 Mar 12. PMID 25887846, Free PMC Article
    2. Overexpression of a Drosophila homolog of apolipoprotein D leads to increased stress resistance and extended lifespan. Walker DW, et al. Curr Biol, 2006 Apr 4. PMID 16581512
    3. Protecting cells by protecting their vulnerable lysosomes: Identification of a new mechanism for preserving lysosomal functional integrity upon oxidative stress. Pascua-Maestro R, et al. PLoS Genet, 2017 Feb. PMID 28182653, Free PMC Article
    4. Altered lipid metabolism in a Drosophila model of Friedreich's ataxia. Navarro JA, et al. Hum Mol Genet, 2010 Jul 15. PMID 20460268, Free PMC Article
    5. Grasshopper Lazarillo, a GPI-anchored Lipocalin, increases Drosophila longevity and stress resistance, and functionally replaces its secreted homolog NLaz. Ruiz M, et al. Insect Biochem Mol Biol, 2012 Oct. PMID 22846641

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lack of GLaz reduces longevity in males but not in females.
      Title: Sex-dependent modulation of longevity by two Drosophila homologues of human Apolipoprotein D, GLaz and NLaz.
    2. GLaz has a protective role in stress situations and that its absence reduces lifespan and accelerates neurodegeneration.
      Title: Loss of glial lazarillo, a homolog of apolipoprotein D, reduces lifespan and stress resistance in Drosophila.
    3. Overexpression of GLaz is protective against behavioral deficits caused in normal flies subjected to hypoxia, followed by recovery under normoxia.
      Title: Overexpression of a Drosophila homolog of apolipoprotein D leads to increased stress resistance and extended lifespan.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables lipoprotein particle receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to oxidative stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in lipid homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to reactive oxygen species IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glial lazarillo
    Names
    CG4604-PA
    CG4604-PB
    CG4604-PC
    CG4604-PD
    CG4604-PE
    CG4604-PF
    GLaz-PA
    GLaz-PB
    GLaz-PC
    GLaz-PD
    GLaz-PE
    GLaz-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      13163959..13168032 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274011.2 → NP_001260940.1  glial lazarillo, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260940.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z991, H1UUJ2
      Conserved Domains (1) summary
      pfam00061
      Location:48 → 202
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

    2. NM_001274007.2 → NP_001260936.1  glial lazarillo, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260936.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z991, H1UUJ2
      Conserved Domains (1) summary
      pfam00061
      Location:48 → 202
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

    3. NM_079003.5 → NP_523727.2  glial lazarillo, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523727.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z991, H1UUJ2
      Related
      FBpp0086885
      Conserved Domains (1) summary
      pfam00061
      Location:48 → 202
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

    4. NM_001274009.2 → NP_001260938.1  glial lazarillo, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260938.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z991, H1UUJ2
      Conserved Domains (1) summary
      pfam00061
      Location:48 → 202
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

    5. NM_001274010.2 → NP_001260939.1  glial lazarillo, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260939.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z991, H1UUJ2
      Conserved Domains (1) summary
      pfam00061
      Location:48 → 202
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

    6. NM_001274008.2 → NP_001260937.1  glial lazarillo, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260937.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z991, H1UUJ2
      Conserved Domains (1) summary
      pfam00061
      Location:48 → 202
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z991 A1Z991
    Q7K024 Q7K024
    Q9NAZ3 Q9NAZ3

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