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    TppII Tripeptidyl-peptidase II [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36444, updated on 9-Dec-2024

    Summary

    Official Symbol
    TppIIprovided by FlyBase
    Official Full Name
    Tripeptidyl-peptidase IIprovided by FlyBase
    Primary source
    FLYBASE:FBgn0020370
    Locus tag
    Dmel_CG3991
    See related
    AllianceGenome:FB:FBgn0020370
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.127; CG3991; Dmel\CG3991; dTPP II; dTPPII; l(2)k14301; TPP II; TPP2; TPPII
    Summary
    Enables identical protein binding activity and tripeptidyl-peptidase activity. Involved in proteolysis. Located in cytosol. Part of protein-containing complex. Is expressed in several structures, including Malpighian tubule primordium; adult head; epithelium; gland; and gut section. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human TPP2 (tripeptidyl peptidase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See TppII in Genome Data Viewer
    Location:
    49F4-49F4; 2-68 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13152885..13159141, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9040390..9046646, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Chromosome associated protein G Neighboring gene Activated Cdc42 kinase-like Neighboring gene NADH dehydrogenase (ubiquinone) MWFE subunit Neighboring gene Neurospecific receptor kinase Neighboring gene uncharacterized protein Neighboring gene Glial Lazarillo

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    mobile_element

    • Loc: c13156015-13155983 mobile_element_type = transposon:INE-1{}5010

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables serine hydrolase activity HDA PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables tripeptidyl-peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables tripeptidyl-peptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables tripeptidyl-peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    Tripeptidyl-peptidase II
    Names
    CG3991-PA
    CG3991-PD
    CG3991-PE
    CG3991-PF
    TppII-PA
    TppII-PD
    TppII-PE
    TppII-PF
    tripeptidyl peptidase II
    tripeptidyl-peptidase II
    tripeptidylpeptidase II
    NP_001286376.1
    NP_001286377.1
    NP_477247.1
    NP_725252.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      13152885..13159141 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165966.2NP_725252.1  Tripeptidyl-peptidase II, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725252.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B5RJ14, O76251, Q8IH59, Q8ML58, Q9V6K1
      Related
      FBpp0086887
      Conserved Domains (4) summary
      cd04857
      Location:101589
      Peptidases_S8_Tripeptidyl_Aminopeptidase_II; Peptidase S8 family domain in Tripeptidyl aminopeptidases_II
      pfam00082
      Location:331600
      Peptidase_S8; Subtilase family
      pfam12580
      Location:8921073
      TPPII; Tripeptidyl peptidase II
      pfam12583
      Location:11441257
      TPPII_N; Tripeptidyl peptidase II N terminal
    2. NM_001299447.1NP_001286376.1  Tripeptidyl-peptidase II, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286376.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LGC0
      Conserved Domains (4) summary
      cd04857
      Location:14502
      Peptidases_S8_Tripeptidyl_Aminopeptidase_II; Peptidase S8 family domain in Tripeptidyl aminopeptidases_II
      pfam00082
      Location:244513
      Peptidase_S8; Subtilase family
      pfam12580
      Location:805986
      TPPII; Tripeptidyl peptidase II
      pfam12583
      Location:10571170
      TPPII_N; Tripeptidyl peptidase II N terminal
    3. NM_057899.3NP_477247.1  Tripeptidyl-peptidase II, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477247.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LGC0
      Related
      FBpp0086888
      Conserved Domains (4) summary
      cd04857
      Location:14502
      Peptidases_S8_Tripeptidyl_Aminopeptidase_II; Peptidase S8 family domain in Tripeptidyl aminopeptidases_II
      pfam00082
      Location:244513
      Peptidase_S8; Subtilase family
      pfam12580
      Location:805986
      TPPII; Tripeptidyl peptidase II
      pfam12583
      Location:10571170
      TPPII_N; Tripeptidyl peptidase II N terminal
    4. NM_001299448.1NP_001286377.1  Tripeptidyl-peptidase II, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286377.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LF88
      Conserved Domains (4) summary
      pfam00082
      Location:244534
      Peptidase_S8; Subtilase family
      pfam12580
      Location:8261007
      TPPII; Tripeptidyl peptidase II
      pfam12583
      Location:10781191
      TPPII_N; Tripeptidyl peptidase II N terminal
      cl10459
      Location:14523
      Peptidases_S8_S53; Peptidase domain in the S8 and S53 families