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    GalT1 beta1,3-galactosyltransferase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36279, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GalT1provided by FlyBase
    Official Full Name
    beta1,3-galactosyltransferase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0053145
    Locus tag
    Dmel_CG33145
    See related
    AllianceGenome:FB:FBgn0053145
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG33145; CG8976; dbeta3GnT; Dmel\CG33145; DmGalT1
    Summary
    Enables beta-1,3-galactosyltransferase activity. Involved in protein N-linked glycosylation. Predicted to be located in membrane. Predicted to be active in Golgi membrane. Is expressed in organism. Orthologous to several human genes including B3GALT1 (beta-1,3-galactosyltransferase 1) and B3GALT2 (beta-1,3-galactosyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See GalT1 in Genome Data Viewer
    Location:
    48D5-48D5; 2-65 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11980577..11982956, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7868082..7870461, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene ADD domain-containing protein 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ribonucleoside diphosphate reductase small subunit Neighboring gene uncharacterized protein Neighboring gene rhomboid-7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Diversity and functions of protein glycosylation in insects. Walski T, et al. Insect Biochem Mol Biol, 2017 Apr. PMID 28232040
    2. Functional analysis of glycosylation using Drosophila melanogaster. Nishihara S. Glycoconj J, 2020 Feb. PMID 31773367
    3. A genome-wide CRISPR screen identifies DPM1 as a modifier of DPAGT1 deficiency and ER stress. Dalton HM, et al. PLoS Genet, 2022 Sep. PMID 36166480, Free PMC Article
    4. Genes and biological processes controlled by the Drosophila FOXA orthologue Fork head. Liu Y, et al. Insect Mol Biol, 2008 Apr. PMID 18353099
    5. Phenotype-based clustering of glycosylation-related genes by RNAi-mediated gene silencing. Yamamoto-Hino M, et al. Genes Cells, 2015 Jun. PMID 25940448, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables beta-1,3-galactosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glycosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hexosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein N-linked glycosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    beta1,3-galactosyltransferase 1
    Names
    CG33145-PA
    CG33145-PB
    GalT1-PA
    GalT1-PB
    beta1,3-galactosyltransferase
    NP_788328.1
    NP_788329.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      11980577..11982956 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_176149.2 → NP_788329.1  beta1,3-galactosyltransferase 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788329.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JZU2
      Related
      FBpp0087153
      Conserved Domains (1) summary
      cl21608
      Location:204 → 280
      Galactosyl_T; Galactosyltransferase

    2. NM_176148.2 → NP_788328.1  beta1,3-galactosyltransferase 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788328.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z8R6
      Related
      FBpp0087154
      Conserved Domains (1) summary
      cl21608
      Location:204 → 407
      Galactosyl_T; Galactosyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z8R6 A1Z8R6
    Q7JZU2 Q7JZU2

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