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    Elp2 Elongator complex protein 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36123, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Elp2provided by FlyBase
    Official Full Name
    Elongator complex protein 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0033540
    Locus tag
    Dmel_CG11887
    See related
    AllianceGenome:FB:FBgn0033540
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1187; CG11887; D-elp2; Dmel\CG11887; elp-2; elp2; Stip; StIP
    Summary
    Involved in establishment of mitotic spindle asymmetry. Part of elongator holoenzyme complex. Is expressed in several structures, including anterior endoderm; embryonic/larval midgut primordium; gut section; hindgut proper primordium; and larval muscle system. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 58. Orthologous to human ELP2 (elongator acetyltransferase complex subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Elp2 in Genome Data Viewer
    Location:
    47B1-47B1; 2-63 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10645735..10648634)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6533240..6536139)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene G protein-coupled receptor kinase interacting ArfGAP Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44452

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Relating past and present diet to phenotypic and transcriptomic variation in the fruit fly. May CM, et al. BMC Genomics, 2017 Aug 22. PMID 28830340, Free PMC Article
    2. Elongator stabilizes microtubules to control central spindle asymmetry and polarized trafficking of cell fate determinants. Planelles-Herrero VJ, et al. Nat Cell Biol, 2022 Nov. PMID 36302967, Free PMC Article
    3. Genomic signatures of experimental adaptive radiation in Drosophila. Michalak P, et al. Mol Ecol, 2019 Feb. PMID 30375065
    4. Chromatin regulators in neurodevelopment and disease: Analysis of fly neural circuits provides insights: Networks of chromatin regulators and transcription factors underlie Drosophila neurogenesis and cognitive defects in intellectual disability and neuropsychiatric disorder models. Taniguchi H, et al. Bioessays, 2014 Sep. PMID 25067789
    5. A large-scale RNAi screen reveals that mitochondrial function is important for meiotic chromosome organization in oocytes. Nieken KJ, et al. Chromosoma, 2023 Mar. PMID 36648541, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in establishment of mitotic spindle asymmetry IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tRNA wobble uridine modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of elongator holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of elongator holoenzyme complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of elongator holoenzyme complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    elongator complex protein 2
    Names
    CG11887-PA
    Elp2-PA
    StIP

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      10645735..10648634
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136756.4 → NP_610600.1  elongator complex protein 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610600.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7K4B3
      Related
      FBpp0087307
      Conserved Domains (3) summary
      COG2319
      Location:237 → 741
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:104 → 145
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:50 → 412
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K4B3.1 Q7K4B3

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