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    wun2 wunen-2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 53558, updated on 9-Dec-2024

    Summary

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    Official Symbol
    wun2provided by FlyBase
    Official Full Name
    wunen-2provided by FlyBase
    Primary source
    FLYBASE:FBgn0041087
    Locus tag
    Dmel_CG8805
    See related
    AllianceGenome:FB:FBgn0041087
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:CK02248; CG8805; CK02248; Dmel\CG8805; DrPAP2[G]; LPP-like; N14; Pap2G; Tunen; wun-2; WUN-like; Wun2; Wunen-2
    Summary
    Enables lipid phosphatase activity and lipid transporter activity. Involved in germ cell development; germ cell repulsion; and pole cell development. Located in apical part of cell and plasma membrane. Is expressed in adult head; embryonic/larval midgut primordium; epidermis; hindgut proper primordium; and neuroblasts. Orthologous to several human genes including PLPP1 (phospholipid phosphatase 1) and PLPP2 (phospholipid phosphatase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See wun2 in Genome Data Viewer
    Location:
    45D4-45D5; 2-60 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9414342..9417846)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5301847..5305351)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene lethal (2) k10201 Neighboring gene uncharacterized protein Neighboring gene wunen Neighboring gene uncharacterized protein Neighboring gene preli-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Quantifying the range of a lipid phosphate signal in vivo. Mukherjee A, et al. J Cell Sci, 2013 Dec 1. PMID 24006260
    2. Quantitative Differences in a Single Maternal Factor Determine Survival Probabilities among Drosophila Germ Cells. Slaidina M, et al. Curr Biol, 2017 Jan 23. PMID 28065608, Free PMC Article
    3. Lysophosphatidic acid signaling: how a small lipid does big things. Luquain C, et al. Trends Biochem Sci, 2003 Jul. PMID 12878005
    4. Lysophosphatidic acid and sphingosine 1-phosphate biology: the role of lipid phosphate phosphatases. Pyne S, et al. Semin Cell Dev Biol, 2004 Oct. PMID 15271294
    5. Soma-germ line competition for lipid phosphate uptake regulates germ cell migration and survival. Renault AD, et al. Science, 2004 Sep 24. PMID 15331773

    See all (110) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. germ cell survival and directionality of migration are controlled by two lipid phosphate phosphatases (LPP), wunen (wun) and wunen-2 (wun2). wun wun2 double mutant analysis reveals that the two genes act redundantly in primordial germ cells.
      Title: Lipid phosphate phosphatase activity regulates dispersal and bilateral sorting of embryonic germ cells in Drosophila.
    2. Drosophila melanogaster lipid phosphate phosphatases Wunen and Wunen 2 have roles in lateral migration and germ cell elimination
      Title: Control of lateral migration and germ cell elimination by the Drosophila melanogaster lipid phosphate phosphatases Wunen and Wunen 2.
    3. functions in germ cells, enabling them to perceive the wun/wun2-related signal from the soma
      Title: Soma-germ line competition for lipid phosphate uptake regulates germ cell migration and survival.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables lipid phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lipid transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidate phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ectopic germ cell programmed cell death TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in germ cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germ cell migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in germ cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germ cell migration TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in germ cell repulsion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in germ cell repulsion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in phospholipid dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pole cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    wunen-2
    Names
    CG8805-PA
    CG8805-PB
    Wunen2
    wun2-PA
    wun2-PB
    wunen 2
    NP_001286248.1
    NP_524991.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9414342..9417846
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299319.1 → NP_001286248.1  wunen-2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286248.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LEJ6
      Conserved Domains (1) summary
      cd03384
      Location:87 → 242
      PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

    2. NM_080252.4 → NP_524991.1  wunen-2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524991.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KGH1, Q8IGU7, Q9NGZ2
      Related
      FBpp0087590
      Conserved Domains (1) summary
      cd03384
      Location:191 → 346
      PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LEJ6 A0A0B4LEJ6
    Q7KGH1 Q7KGH1
    Q8IGU7 Q8IGU7
    Q9NGZ2 Q9NGZ2

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