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    Br140 Bromodomain-containing protein, 140kD [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35648, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Br140provided by FlyBase
    Official Full Name
    Bromodomain-containing protein, 140kDprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033155
    Locus tag
    Dmel_CG1845
    See related
    AllianceGenome:FB:FBgn0033155
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1845; Dmel\CG1845
    Summary
    Enables acetyltransferase activator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Part of MOZ/MORF histone acetyltransferase complex. Is expressed in several structures, including embryonic anal pad; embryonic dorsal epidermis; embryonic ventral epidermis; lateral cord; and ventral midline of embryo. Human ortholog(s) of this gene implicated in bipolar disorder and schizophrenia. Orthologous to several human genes including BRPF1 (bromodomain and PHD finger containing 1) and BRPF3 (bromodomain and PHD finger containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Br140 in Genome Data Viewer
    Location:
    43A2-43A2; 2-55 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7272275..7278101, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3159780..3165606, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45280 Neighboring gene uncharacterized protein Neighboring gene Inner centromere protein Neighboring gene pawn

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Aclarubicin stimulates RNA polymerase II elongation at closely spaced divergent promoters. Wooten M, et al. Sci Adv, 2023 Jun 16. PMID 37315134, Free PMC Article
    2. Essential roles of Drosophila inner centromere protein (INCENP) and aurora B in histone H3 phosphorylation, metaphase chromosome alignment, kinetochore disjunction, and chromosome segregation. Adams RR, et al. J Cell Biol, 2001 May 14. PMID 11352945, Free PMC Article
    3. The Enok acetyltransferase complex interacts with Elg1 and negatively regulates PCNA unloading to promote the G1/S transition. Huang F, et al. Genes Dev, 2016 May 15. PMID 27198229, Free PMC Article
    4. Bivalent complexes of PRC1 with orthologs of BRD4 and MOZ/MORF target developmental genes in Drosophila. Kang H, et al. Genes Dev, 2017 Oct 1. PMID 29070704, Free PMC Article
    5. Polycomb purification by in vivo biotinylation tagging reveals cohesin and Trithorax group proteins as interaction partners. Strübbe G, et al. Proc Natl Acad Sci U S A, 2011 Apr 5. PMID 21415365, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables acetyltransferase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of MOZ/MORF histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MOZ/MORF histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Bromodomain-containing protein, 140kD
    Names
    Br140-PA
    Br140-PB
    CG1845-PA
    CG1845-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7272275..7278101 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299226.1 → NP_001286155.1  Bromodomain-containing protein, 140kD, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286155.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7JVP4
      Conserved Domains (5) summary
      cd05839
      Location:1303 → 1414
      BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
      cd05512
      Location:615 → 712
      Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
      cd15572
      Location:283 → 336
      PHD_BRPF; PHD finger found in bromodomain and PHD finger-containing (BRPF) proteins
      cd15670
      Location:340 → 456
      ePHD_BRPF; Extended PHD finger found in BRPF proteins
      pfam10513
      Location:192 → 264
      EPL1; Enhancer of polycomb-like

    2. NM_136422.3 → NP_610266.1  Bromodomain-containing protein, 140kD, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610266.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7JVP4
      Related
      FBpp0088092
      Conserved Domains (5) summary
      cd05839
      Location:1303 → 1414
      BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
      cd05512
      Location:615 → 712
      Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
      cd15572
      Location:283 → 336
      PHD_BRPF; PHD finger found in bromodomain and PHD finger-containing (BRPF) proteins
      cd15670
      Location:340 → 456
      ePHD_BRPF; Extended PHD finger found in BRPF proteins
      pfam10513
      Location:192 → 264
      EPL1; Enhancer of polycomb-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JVP4.1 Q7JVP4

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