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    Ude Uracil-DNA degrading factor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42953, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Udeprovided by FlyBase
    Official Full Name
    Uracil-DNA degrading factorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039226
    Locus tag
    Dmel_CG18410
    See related
    AllianceGenome:FB:FBgn0039226
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG18410; Dmel\CG18410; UDE
    Summary
    Enables DNA binding activity and RNA binding activity. Involved in DNA catabolic process and pupation. Is expressed in several structures, including embryonic dorsal apodeme; embryonic dorsal epidermis; embryonic head sensory system; embryonic ventral apodeme; and embryonic/larval oenocyte. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ude in Genome Data Viewer
    Location:
    96A22-96A22; 3-85 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24797460..24799668, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20623182..20625390, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ets96B Neighboring gene polybromo Neighboring gene lilipod Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel fruitfly protein under developmental control degrades uracil-DNA. Békési A, et al. Biochem Biophys Res Commun, 2007 Apr 13. PMID 17306761
    2. Secondary Structure Prediction of Protein Constructs Using Random Incremental Truncation and Vacuum-Ultraviolet CD Spectroscopy. Pukáncsik M, et al. PLoS One, 2016. PMID 27273007, Free PMC Article
    3. Association of RNA with the uracil-DNA-degrading factor has major conformational effects and is potentially involved in protein folding. Bekesi A, et al. FEBS J, 2011 Jan. PMID 21134127
    4. Physiological truncation and domain organization of a novel uracil-DNA-degrading factor. Pukáncsik M, et al. FEBS J, 2010 Mar. PMID 20121948
    5. Drosophila proteins involved in metabolism of uracil-DNA possess different types of nuclear localization signals. Merényi G, et al. FEBS J, 2010 May. PMID 20412059

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A RNA-UDE complex may be formed via a cofolding mechanism. UDE may possess functional roles related to its RNA binding in addition to its uracil-DNA-degrading activity.
      Title: Association of RNA with the uracil-DNA-degrading factor has major conformational effects and is potentially involved in protein folding.
    2. Subcellular targeting of UDE protein containing specific site mutations in the localization signal sequence
      Title: Drosophila proteins involved in metabolism of uracil-DNA possess different types of nuclear localization signals.
    3. UDE represents a new class of proteins that process uracil-DNA with potential involvement in metamorphosis.
      Title: A novel fruitfly protein under developmental control degrades uracil-DNA.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables double-stranded RNA-specific ribonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables uracil DNA N-glycosylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in pupation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Uracil-DNA degrading factor
    Names
    CG18410-PB
    CG18410-PC
    CG18410-PD
    Ude-PB
    Ude-PC
    Ude-PD
    uracil-DNA degrading factor
    uracil-DNA-degrading factor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      24797460..24799668 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300585.1 → NP_001287514.1  Uracil-DNA degrading factor, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287514.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KS11, Q961C4, Q9VC37

    2. NM_143030.3 → NP_651287.4  Uracil-DNA degrading factor, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651287.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KS11, Q961C4, Q9VC37

    3. NM_001276000.1 → NP_001262929.1  Uracil-DNA degrading factor, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262929.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KS11, Q961C4, Q9VC37
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KS11 Q7KS11
    Q961C4 Q961C4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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