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    mthl5 methuselah-like 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41438, updated on 9-Dec-2024

    Summary

    Official Symbol
    mthl5provided by FlyBase
    Official Full Name
    methuselah-like 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0037960
    Locus tag
    Dmel_CG6965
    See related
    AllianceGenome:FB:FBgn0037960
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0170980.70; anon-WO0170980.71; CG6965; Dmel\CG6965; Gia; Mth-5; mth15; Mthl5
    Summary
    Predicted to enable G protein-coupled receptor activity. Involved in heart morphogenesis. Predicted to be located in membrane. Is expressed in several structures, including antennal anlage; central brain anlage; embryonic cardioblast; ganglia; and visceral mesoderm derivative. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See mthl5 in Genome Data Viewer
    Location:
    87A1-87A1; 3-51 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11883938..11887168, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7709660..7712890, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene shadow Neighboring gene Dynein axonemal light intermediate chain 1 Neighboring gene Cadherin 87A Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables G protein-coupled receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in determination of adult lifespan ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in heart morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to starvation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    General protein information

    Preferred Names
    methuselah-like 5
    Names
    CG6965-PA
    CG6965-PB
    GPCR in aorta
    Methuselah-like 5
    Mth-like 5
    mthl5-PA
    mthl5-PB

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      11883938..11887168 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141869.3NP_650126.2  methuselah-like 5, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650126.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MRB8, Q9VGG8
      UniProtKB/TrEMBL
      D0Z729
      Related
      FBpp0081989
      Conserved Domains (1) summary
      cl21561
      Location:212450
      7tm_4; Olfactory receptor
    2. NM_001300362.1NP_001287291.1  methuselah-like 5, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287291.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LH68
      Conserved Domains (1) summary
      cl21561
      Location:212451
      7tm_4; Olfactory receptor