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    CG5359 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41222, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG5359provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037773
    Locus tag
    Dmel_CG5359
    See related
    AllianceGenome:FB:FBgn0037773
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE37471; Dmel\CG5359
    Summary
    Predicted to enable dynein intermediate chain binding activity. Predicted to be involved in microtubule-based movement. Predicted to be part of cytoplasmic dynein complex. Predicted to be active in cytoplasm. Is expressed in several structures, including central brain primordium; dorsal sensory complex primordium; ganglia; sensory nervous system primordium; and sensory organ cell. Human ortholog(s) of this gene implicated in asphyxiating thoracic dystrophy. Orthologous to human DYNLT2B (dynein light chain Tctex-type 2B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG5359 in Genome Data Viewer
    Location:
    85F5-85F5; 3-49 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9999771..10001276, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5825493..5826998, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Glucose transporter 4 enhancer factor Neighboring gene mir-9371 stem loop Neighboring gene Serpin 85F Neighboring gene Gustatory receptor 85a Neighboring gene Molecule interacting with CasL Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis of Drosophila melanogaster testis transcriptome. Vedelek V, et al. BMC Genomics, 2018 Sep 24. PMID 30249207, Free PMC Article
    2. Drosophila MICAL regulates myofilament organization and synaptic structure. Beuchle D, et al. Mech Dev, 2007 May. PMID 17350233
    3. Dyneins across eukaryotes: a comparative genomic analysis. Wickstead B, et al. Traffic, 2007 Dec. PMID 17897317, Free PMC Article
    4. Synergistic interactions between Drosophila orthologues of genes spanned by de novo human CNVs support multiple-hit models of autism. Grice SJ, et al. PLoS Genet, 2015 Mar. PMID 25816101, Free PMC Article
    5. NCBP2 modulates neurodevelopmental defects of the 3q29 deletion in Drosophila and Xenopus laevis models. Singh MD, et al. PLoS Genet, 2020 Feb. PMID 32053595, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables dynein intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein intermediate chain binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule-based movement ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytoplasmic dynein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of dynein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG5359-PA
    CG5359-PB
    CG5359-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9999771..10001276 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001260084.2 → NP_001247013.1  uncharacterized protein Dmel_CG5359, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247013.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VH45
      Conserved Domains (1) summary
      pfam03645
      Location:74 → 171
      Tctex-1; Tctex-1 family

    2. NM_141709.3 → NP_649966.1  uncharacterized protein Dmel_CG5359, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649966.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VH45
      Related
      FBpp0081693
      Conserved Domains (1) summary
      pfam03645
      Location:74 → 171
      Tctex-1; Tctex-1 family

    3. NM_001170108.2 → NP_001163579.1  uncharacterized protein Dmel_CG5359, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163579.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VH45
      Conserved Domains (1) summary
      pfam03645
      Location:74 → 171
      Tctex-1; Tctex-1 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VH45 Q9VH45

    Gene LinkOut

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