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    stnA stoned A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3355164, updated on 4-Jan-2025

    Summary

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    Official Symbol
    stnAprovided by FlyBase
    Official Full Name
    stoned Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0016976
    Locus tag
    Dmel_CG12500
    See related
    AllianceGenome:FB:FBgn0016976
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    20; 31; 32; 8P1; CG12500; CG40306; Dmel\CG12500; l(1)13-20; l(1)20Bc; l(1)X-3; l8P1; lR9-10; ORF1; sesC; stn; stn-A; StnA; STNA; x-3; X-3; X-43; X3
    Summary
    Involved in synaptic vesicle endocytosis and synaptic vesicle transport. Located in endocytic vesicle and synaptic vesicle. Is expressed in adult abdomen; adult head; and adult thorax. [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See stnA in Genome Data Viewer
    Location:
    20F3-20F3; 1-66 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (22980722..23004648, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (22382558..22406484, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene stoned B Neighboring gene antisense RNA:CR45009 Neighboring gene long non-coding RNA:CR45010 Neighboring gene alpha1,3-fucosyltransferase C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An altered electroretinogram transient associated with an unusual jump response in a mutant of Drosophila. Kelly LE. Cell Mol Neurobiol, 1983 Jun. PMID 6418384
    2. The regulation of phosphorylation of a specific protein in synaptosomal fractions from Drosophila heads: the effects of light and two visual mutants. Kelly LE. Cell Mol Neurobiol, 1983 Jun. PMID 6317178
    3. Ca2+ regulates the Drosophila Stoned-A and Stoned-B proteins interaction with the C2B domain of Synaptotagmin-1. Soekmadji C, et al. PLoS One, 2012. PMID 22701718, Free PMC Article
    4. Effective translation of the second cistron in two Drosophila dicistronic transcripts is determined by the absence of in-frame AUG codons in the first cistron. Wall AA, et al. J Biol Chem, 2005 Jul 29. PMID 15951443
    5. A product of the Drosophila stoned locus regulates neurotransmitter release. Stimson DT, et al. J Neurosci, 1998 Dec 1. PMID 9822725, Free PMC Article

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Stoned proteins may regulate sustainable neurotransmission in vivo by binding to Ca(2+)-bound Synaptotagmin-1 associated synaptic vesicles.
      Title: Ca2+ regulates the Drosophila Stoned-A and Stoned-B proteins interaction with the C2B domain of Synaptotagmin-1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c22983800-22983677 mobile_element_type = transposon:INE-1{}3879
    • Loc: c22984008-22983905 mobile_element_type = transposon:INE-1{}3880
    • Loc: c22994189-22994067 mobile_element_type = transposon:INE-1{}3883

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in synaptic vesicle endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endocytic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synaptic vesicle IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    located_in synaptic vesicle IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    stoned A
    Names
    CG12500-PC
    CG12500-PD
    CG12500-PE
    CG12500-PF
    section 20
    section 31
    section 32
    stnA-PC
    stnA-PD
    stnA-PE
    stnA-PF
    stoned
    stonedA
    stress-sensitive-C

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      22980722..23004648 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001042851.3 → NP_001036316.1  stoned A, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036316.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24211, Q7PLF2, Q9W5M8
      UniProtKB/TrEMBL
      A4V4W0

    2. NM_001298609.1 → NP_001285538.1  stoned A, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285538.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24211, Q7PLF2, Q9W5M8
      UniProtKB/TrEMBL
      A4V4W0

    3. NM_001042852.3 → NP_001036317.1  stoned A, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036317.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24211, Q7PLF2, Q9W5M8
      UniProtKB/TrEMBL
      A4V4W0

    4. NM_001298608.1 → NP_001285537.1  stoned A, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285537.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24211, Q7PLF2, Q9W5M8
      UniProtKB/TrEMBL
      A4V4W0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4V4W0 A4V4W0
    Q24211.3 Q24211

    Gene LinkOut

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